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prkar1ab protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b [ Danio rerio (zebrafish) ]

Gene ID: 550427, updated on 2-Nov-2024

Summary

Official Symbol
prkar1abprovided by ZNC
Official Full Name
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-238
See related
Ensembl:ENSDARG00000101755 AllianceGenome:ZFIN:ZDB-GENE-050417-238
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:112145
Summary
Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease 1. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See prkar1ab in Genome Data Viewer
Location:
chromosome: 12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (2870678..2895802)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (2835945..2861069)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene ubiquitin domain containing 1b Neighboring gene MMS19 homolog, cytosolic iron-sulfur assembly component Neighboring gene zinc finger DHHC-type palmitoyltransferase 16b Neighboring gene FAM20A golgi associated secretory pathway pseudokinase Neighboring gene cilia- and flagella-associated protein 337 Neighboring gene uncharacterized LOC137496785

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
 
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP-dependent protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A catalytic subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cAMP-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b
NP_001017732.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017732.1NP_001017732.1  protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b

    See identical proteins and their annotated locations for NP_001017732.1

    Status: PROVISIONAL

    Source sequence(s)
    BC093222
    UniProtKB/TrEMBL
    Q567D1
    Related
    ENSDARP00000138282.1, ENSDART00000165225.2
    Conserved Domains (3) summary
    cd12101
    Location:1362
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:247357
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:135244
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    2870678..2895802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)