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vaspb vasodilator stimulated phosphoprotein b [ Danio rerio (zebrafish) ]

Gene ID: 550487, updated on 17-Aug-2024

Summary

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Official Symbol
vaspbprovided by ZNC
Official Full Name
vasodilator stimulated phosphoprotein bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7118
See related
Ensembl:ENSDARG00000017105 AllianceGenome:ZFIN:ZDB-GENE-030131-7118
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
vasp; wu:fb23b04; wu:fk84g05; zgc:110347; si:dkey-113g17.1; si:ch211-202c21.1
Summary
Predicted to enable SH3 domain binding activity and profilin binding activity. Predicted to be involved in actin cytoskeleton organization; nervous system development; and positive regulation of actin filament polymerization. Predicted to act upstream of or within actin polymerization or depolymerization. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; epidermis; pectoral fin; pharyngeal arch; and solid lens vesicle. Orthologous to human VASP (vasodilator stimulated phosphoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See vaspb in Genome Data Viewer
Location:
chromosome: 18
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (40761913..40856360, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (40771721..40866180, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene cyclin P Neighboring gene v-akt murine thymoma viral oncogene homolog 2 Neighboring gene transfer RNA alanine (anticodon UGC) Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene transfer RNA tryptophan (anticodon CCA)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis. Fischer RS, et al. Dev Biol, 2019 Jul 1. PMID 30193787, Free PMC Article
  2. Akt2 modulates glucose availability and downstream apoptotic pathways during development. Jensen PJ, et al. J Biol Chem, 2010 Jun 4. PMID 20356836, Free PMC Article
  3. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Wu Y, et al. Sci Rep, 2017 Jun 22. PMID 28642470, Free PMC Article
  4. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
  5. Selecting biologically informative genes in co-expression networks with a centrality score. Azuaje FJ. Biol Direct, 2014 Jun 19. PMID 24947308, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables profilin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural tube closure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein enabled homolog; vasodilator stimulated phosphoprotein b; vasodilator-stimulated phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    40761913..40856360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173680.4 → XP_005173737.1  vasodilator-stimulated phosphoprotein isoform X2

    UniProtKB/TrEMBL
    A0A8M2BKY8
    Conserved Domains (2) summary
    cd01207
    Location:5 → 114
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:392 → 422
    VASP_tetra; VASP tetramerization domain

  2. XM_005173679.4 → XP_005173736.1  vasodilator-stimulated phosphoprotein isoform X1

    UniProtKB/TrEMBL
    A0A8M2BKY2, Q1LVK6
    Related
    ENSDARP00000089635.3, ENSDART00000098865.5
    Conserved Domains (2) summary
    cd01207
    Location:5 → 114
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:411 → 441
    VASP_tetra; VASP tetramerization domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395045.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    3633..78922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473340.1 → XP_021329015.1  protein enabled homolog isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q724
    Conserved Domains (1) summary
    cd01207
    Location:5 → 114
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017790.2: Suppressed sequence

    Description
    NM_001017790.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

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