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med4 mediator complex subunit 4 [ Danio rerio (zebrafish) ]

Gene ID: 550582, updated on 12-Sep-2024

Summary

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Official Symbol
med4provided by ZNC
Official Full Name
mediator complex subunit 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-438
See related
Ensembl:ENSDARG00000041503 AllianceGenome:ZFIN:ZDB-GENE-050417-438
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110646
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex. Orthologous to human MED4 (mediator complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See med4 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (25320680..25328476, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (25509811..25517607, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene esterase D/formylglutathione hydrolase Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a Neighboring gene integral membrane protein 2Bb Neighboring gene enhancer of polycomb homolog 2 (Drosophila)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017883.1 → NP_001017883.1  mediator of RNA polymerase II transcription subunit 4

    See identical proteins and their annotated locations for NP_001017883.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092965
    UniProtKB/Swiss-Prot
    Q561X3
    UniProtKB/TrEMBL
    B2GPG1
    Related
    ENSDARP00000060839.4, ENSDART00000060840.5
    Conserved Domains (1) summary
    pfam10018
    Location:49 → 186
    Med4; Vitamin-D-receptor interacting Mediator subunit 4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    25320680..25328476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q561X3.1 GenPept UniProtKB/Swiss-Prot:Q561X3

Gene LinkOut

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