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RNF31 ring finger protein 31 [ Homo sapiens (human) ]

Gene ID: 55072, updated on 3-Nov-2024

Summary

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Official Symbol
RNF31provided by HGNC
Official Full Name
ring finger protein 31provided by HGNC
Primary source
HGNC:HGNC:16031
See related
Ensembl:ENSG00000092098 MIM:612487; AllianceGenome:HGNC:16031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOIP; Paul; ZIBRA; IMD115
Summary
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The encoded protein is the E3 ubiquitin-protein ligase component of the linear ubiquitin chain assembly complex. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Expression
Ubiquitous expression in spleen (RPKM 17.0), testis (RPKM 12.6) and 25 other tissues See more
Orthologs
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Genomic context

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See RNF31 in Genome Data Viewer
Location:
14q12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24146875..24160655)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18345184..18358964)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24616084..24629864)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5625 Neighboring gene ER membrane protein complex subunit 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5626 Neighboring gene microRNA 7703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8190 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:24616442-24616942 Neighboring gene proteasome activator subunit 2 Neighboring gene RNA, 5S ribosomal pseudogene 383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8192 Neighboring gene interferon regulatory factor 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:24640701-24641201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8193 Neighboring gene REC8 meiotic recombination protein Neighboring gene importin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC. Oda H, et al. Front Immunol, 2019. PMID 30936877, Free PMC Article
  2. Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression. Zhu J, et al. BMC Cancer, 2016 Jul 26. PMID 27460922, Free PMC Article
  3. Effects of removing a highly conserved disulfide bond in ubiquitin-associated domain of human HOIP on biochemical characteristics. Ma W, et al. Protein Expr Purif, 2022 Feb. PMID 34695570
  4. RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer. Yang H, et al. J Exp Clin Cancer Res, 2022 Dec 29. PMID 36581998, Free PMC Article
  5. The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. Smit JJ, et al. EMBO J, 2012 Oct 3. PMID 22863777, Free PMC Article

See all (194) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation.
    Title: RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation.
  2. Resonance assignments of the PUB domain of the RNF31 protein.
    Title: Resonance assignments of the PUB domain of the RNF31 protein.
  3. RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent apoptosis.
    Title: RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent apoptosis.
  4. RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer.
    Title: RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer.
  5. Effects of removing a highly conserved disulfide bond in ubiquitin-associated domain of human HOIP on biochemical characteristics.
    Title: Effects of removing a highly conserved disulfide bond in ubiquitin-associated domain of human HOIP on biochemical characteristics.
  6. RNF31 mediated ubiquitination of A20 aggravates inflammation and hepatocyte apoptosis through the TLR4/MyD88/NF-kappaB signaling pathway.
    Title: RNF31 mediated ubiquitination of A20 aggravates inflammation and hepatocyte apoptosis through the TLR4/MyD88/NF-κB signaling pathway.
  7. Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.
    Title: Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.
  8. Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders.
    Title: Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders.
  9. Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation.
    Title: Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation.
  10. Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC.
    Title: Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Immunodeficiency 115 with autoinflammation
MedGen: C5882724 OMIM: 620632 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: IRF9

Homology

Clone Names

  • FLJ10111, FLJ23501, MGC19975

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K48-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables linear polyubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CD40 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of necroptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
involved_in positive regulation of xenophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein linear polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein linear polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CD40 receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of LUBAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of LUBAC complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF31
Names
HOIL-1-interacting protein
RING-type E3 ubiquitin transferase RNF31
zinc in-between-RING-finger ubiquitin-associated domain protein
NP_001297261.1
NP_060469.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042234.1 RefSeqGene

    Range
    5624..18781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1315

mRNA and Protein(s)

  1. NM_001310332.2 → NP_001297261.1  E3 ubiquitin-protein ligase RNF31 isoform 2

    See identical proteins and their annotated locations for NP_001297261.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon and an alternate splice site in a 5' exon compared to variant 1, resulting in the use of a downstream translation initiation site. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL136295, AY256461, DA462121
    Consensus CDS
    CCDS81792.1
    UniProtKB/TrEMBL
    H0YNK5
    Related
    ENSP00000453574.1, ENST00000559275.5
    Conserved Domains (5) summary
    smart00647
    Location:628 → 690
    IBR; In Between Ring fingers
    cd14325
    Location:420 → 474
    UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
    sd00029
    Location:153 → 172
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam04981
    Location:548 → 598
    NMD3; NMD3 family
    pfam16678
    Location:332 → 476
    HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase

  2. NM_017999.5 → NP_060469.4  E3 ubiquitin-protein ligase RNF31 isoform 1

    See identical proteins and their annotated locations for NP_060469.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC012077, CN287790
    Consensus CDS
    CCDS41931.1
    UniProtKB/Swiss-Prot
    A0A962, Q86VI2, Q8TEI0, Q96EP0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2
    UniProtKB/TrEMBL
    A0A8V8TQD3
    Related
    ENSP00000315112.6, ENST00000324103.11
    Conserved Domains (6) summary
    cd10464
    Location:52 → 153
    PUB_RNF31; PNGase/UBA or UBX (PUB) domain of the RNF31 (or HOIP) protein
    smart00647
    Location:779 → 841
    IBR; In Between Ring fingers
    cd14325
    Location:571 → 625
    UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
    sd00029
    Location:304 → 323
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam04981
    Location:699 → 749
    NMD3; NMD3 family
    pfam16678
    Location:483 → 627
    HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    24146875..24160655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    447853..461633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18345184..18358964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96EP0.1 GenPept UniProtKB/Swiss-Prot:Q96EP0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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