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RBM41 RNA binding motif protein 41 [ Homo sapiens (human) ]

Gene ID: 55285, updated on 3-Apr-2024

Summary

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Official Symbol
RBM41provided by HGNC
Official Full Name
RNA binding motif protein 41provided by HGNC
Primary source
HGNC:HGNC:25617
See related
Ensembl:ENSG00000089682 AllianceGenome:HGNC:25617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable U12 snRNA binding activity and pre-mRNA intronic binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U12-type spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 2.9), skin (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
Xq22.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (107052102..107118822, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (105488619..105560772, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106295332..106362052, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:106209370-106209870 Neighboring gene MORC family CW-type zinc finger 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20926 Neighboring gene NANOG hESC enhancer GRCh37_chrX:106261730-106262231 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29832 Neighboring gene nucleoporin 62 C-terminal like Neighboring gene GTF3C6 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:106399301-106399461 Neighboring gene dynein axonemal assembly factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor. Tong J, et al. J Proteome Res, 2008 Mar. PMID 18271526
  2. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Gordon DE, et al. Nature, 2020 Jul. PMID 32353859, Free PMC Article
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Zhou Y, et al. Nat Biotechnol, 2023 Jan. PMID 36217030, Free PMC Article
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11016, FLJ13670

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables U12 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pre-mRNA intronic binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016385.2 RefSeqGene

    Range
    5000..61937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001171080.2 → NP_001164551.1  RNA-binding protein 41 isoform 2

    See identical proteins and their annotated locations for NP_001164551.1

    Status: VALIDATED

    Source sequence(s)
    AK001878, AL390039, DA255574
    Consensus CDS
    CCDS55472.1
    UniProtKB/Swiss-Prot
    Q96IZ5
    Related
    ENSP00000361565.1, ENST00000372487.5
    Conserved Domains (1) summary
    cd12239
    Location:308 → 385
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

  2. NM_001324242.2 → NP_001311171.1  RNA-binding protein 41 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Consensus CDS
    CCDS94645.1
    UniProtKB/TrEMBL
    A0A8I5KYC8
    Related
    ENSP00000509650.1, ENST00000685964.1
    Conserved Domains (2) summary
    COG0724
    Location:324 → 414
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12239
    Location:332 → 409
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

  3. NM_001324243.1 → NP_001311172.1  RNA-binding protein 41 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (2) summary
    COG0724
    Location:359 → 449
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12239
    Location:367 → 444
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

  4. NM_001324244.2 → NP_001311173.1  RNA-binding protein 41 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL390039

  5. NM_001394116.1 → NP_001381045.1  RNA-binding protein 41 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    smart00360
    Location:351 → 423
    RRM; RNA recognition motif

  6. NM_001394117.1 → NP_001381046.1  RNA-binding protein 41 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    cd12239
    Location:343 → 420
    RRM2_RBM40_like; RNA recognition motif 2 (RRM2) found in RNA-binding protein 40 (RBM40) and similar proteins

  7. NM_001394118.1 → NP_001381047.1  RNA-binding protein 41 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    smart00360
    Location:324 → 393
    RRM; RNA recognition motif

  8. NM_001394119.1 → NP_001381048.1  RNA-binding protein 41 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    smart00360
    Location:313 → 382
    RRM; RNA recognition motif

  9. NM_001394120.1 → NP_001381049.1  RNA-binding protein 41 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    smart00360
    Location:310 → 382
    RRM; RNA recognition motif

  10. NM_001394121.1 → NP_001381050.1  RNA-binding protein 41 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    smart00360
    Location:289 → 358
    RRM; RNA recognition motif

  11. NM_001394122.1 → NP_001381051.1  RNA-binding protein 41 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    smart00360
    Location:310 → 357
    RRM; RNA recognition motif

  12. NM_001394123.1 → NP_001381052.1  RNA-binding protein 41 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    cd12239
    Location:246 → 321
    RRM2_RBM40_like; RNA recognition motif 2 (RRM2) found in RNA-binding protein 40 (RBM40) and similar proteins

  13. NM_001394124.1 → NP_001381053.1  RNA-binding protein 41 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    smart00360
    Location:246 → 318
    RRM; RNA recognition motif

  14. NM_001394125.1 → NP_001381054.1  RNA-binding protein 41 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    smart00360
    Location:211 → 283
    RRM; RNA recognition motif

  15. NM_001394126.1 → NP_001381055.1  RNA-binding protein 41 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    smart00360
    Location:211 → 283
    RRM; RNA recognition motif

  16. NM_001394127.1 → NP_001381056.1  RNA-binding protein 41 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL390039
    Conserved Domains (1) summary
    smart00360
    Location:206 → 259
    RRM; RNA recognition motif

  17. NM_018301.5 → NP_060771.3  RNA-binding protein 41 isoform 1

    See identical proteins and their annotated locations for NP_060771.3

    Status: VALIDATED

    Source sequence(s)
    AL390039, BC006986, DA255574
    Consensus CDS
    CCDS14526.1
    UniProtKB/Swiss-Prot
    Q5JSN7, Q5JSN8, Q96IZ5, Q9H8F7, Q9NV04
    Related
    ENSP00000361557.3, ENST00000372479.7
    Conserved Domains (1) summary
    cd12239
    Location:308 → 385
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

RNA

  1. NR_136728.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390039

  2. NR_136729.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390039

  3. NR_136730.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK023732, AL390039

  4. NR_136731.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390039

  5. NR_136732.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390039

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    107052102..107118822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442237.1 → XP_047298193.1  RNA-binding protein 41 isoform X2

  2. XM_011530980.4 → XP_011529282.1  RNA-binding protein 41 isoform X1

    See identical proteins and their annotated locations for XP_011529282.1

    Conserved Domains (2) summary
    COG0724
    Location:359 → 449
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12239
    Location:367 → 444
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

  3. XM_047442238.1 → XP_047298194.1  RNA-binding protein 41 isoform X3

  4. XM_047442242.1 → XP_047298198.1  RNA-binding protein 41 isoform X7

  5. XM_047442241.1 → XP_047298197.1  RNA-binding protein 41 isoform X6

    Related
    ENSP00000405522.1, ENST00000434854.1

  6. XM_047442243.1 → XP_047298199.1  RNA-binding protein 41 isoform X8

  7. XM_047442239.1 → XP_047298195.1  RNA-binding protein 41 isoform X4

  8. XM_047442240.1 → XP_047298196.1  RNA-binding protein 41 isoform X5

    Related
    ENSP00000433251.1, ENST00000495517.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    105488619..105560772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327351.1 → XP_054183326.1  RNA-binding protein 41 isoform X9

  2. XM_054327354.1 → XP_054183329.1  RNA-binding protein 41 isoform X10

  3. XM_054327352.1 → XP_054183327.1  RNA-binding protein 41 isoform X9

  4. XM_054327355.1 → XP_054183330.1  RNA-binding protein 41 isoform X2

  5. XM_054327353.1 → XP_054183328.1  RNA-binding protein 41 isoform X1

  6. XM_054327356.1 → XP_054183331.1  RNA-binding protein 41 isoform X3

  7. XM_054327359.1 → XP_054183334.1  RNA-binding protein 41 isoform X6

  8. XM_054327357.1 → XP_054183332.1  RNA-binding protein 41 isoform X4

  9. XM_054327358.1 → XP_054183333.1  RNA-binding protein 41 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96IZ5.2 GenPept UniProtKB/Swiss-Prot:Q96IZ5

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