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brwd3 bromodomain and WD repeat domain containing 3 [ Danio rerio (zebrafish) ]

Gene ID: 553209, updated on 28-Oct-2024

Summary

Official Symbol
brwd3provided by ZNC
Official Full Name
bromodomain and WD repeat domain containing 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-100921-43
See related
Ensembl:ENSDARG00000035540 AllianceGenome:ZFIN:ZDB-GENE-100921-43
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-237j10.3
Summary
Predicted to be involved in cytoskeleton organization; regulation of cell shape; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 93. Orthologous to human BRWD3 (bromodomain and WD repeat domain containing 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See brwd3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (22974033..23022018)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (22469764..22518232)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:ch211-26b3.4 Neighboring gene si:dkey-237j10.2 Neighboring gene high mobility group nucleosomal binding domain 7 Neighboring gene charged multivesicular body protein 1B Neighboring gene cyclic nucleotide gated channel subunit alpha 2b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
bromodomain and WD repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    22974033..23022018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301410.4XP_009299685.1  bromodomain and WD repeat-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3ASD3
    Conserved Domains (5) summary
    cd05496
    Location:12951413
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:11271242
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    COG2319
    Location:176541
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:173495
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:184221
    7WD40; WD40 repeat [structural motif]
  2. XM_009301411.4XP_009299686.1  bromodomain and WD repeat-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B2F0
    Related
    ENSDARP00000027753.11, ENSDART00000020434.11
    Conserved Domains (5) summary
    cd05496
    Location:12941412
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:11261241
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    COG2319
    Location:176541
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:173495
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:184221
    7WD40; WD40 repeat [structural motif]

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394574.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    201838..238195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471594.2XP_021327269.1  bromodomain and WD repeat-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PQW9
    Conserved Domains (4) summary
    cd05496
    Location:12951413
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:11271242
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd00200
    Location:173495
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:184221
    7WD40; WD40 repeat [structural motif]
  2. XM_021471595.2XP_021327270.1  bromodomain and WD repeat-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q1J4
    Conserved Domains (4) summary
    cd05496
    Location:12941412
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:11261241
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd00200
    Location:173495
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:184221
    7WD40; WD40 repeat [structural motif]