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sh3pxd2b SH3 and PX domains 2B [ Danio rerio (zebrafish) ]

Gene ID: 553242, updated on 12-Sep-2024

Summary

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Official Symbol
sh3pxd2bprovided by ZNC
Official Full Name
SH3 and PX domains 2Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060810-52
See related
Ensembl:ENSDARG00000103251 AllianceGenome:ZFIN:ZDB-GENE-060810-52
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7155315; wu:fb09f08
Summary
Predicted to enable superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Predicted to act upstream of or within animal organ development and podosome assembly. Predicted to be located in cell projection and podosome. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; notochord; otic vesicle; segmental plate; and tail bud. Human ortholog(s) of this gene implicated in Frank-Ter Haar syndrome. Orthologous to human SH3PXD2B (SH3 and PX domains 2B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See sh3pxd2b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (42717406..42780082)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (42722117..42784791)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488871 Neighboring gene uncharacterized LOC103909490 Neighboring gene uncharacterized LOC137488872 Neighboring gene serine/threonine kinase 10 Neighboring gene zmp:0000001268

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The novel zebrafish model pretzel demonstrates a central role for SH3PXD2B in defective collagen remodelling and fibrosis in Frank-Ter Haar syndrome. de Vos IJHM, et al. Biol Open, 2020 Dec 29. PMID 33234702, Free PMC Article
  2. Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. Kawahara T, et al. BMC Evol Biol, 2007 Sep 27. PMID 17900370, Free PMC Article
  3. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables superoxide-generating NADPH oxidase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within connective tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3 and PX domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    42717406..42780082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170288.4 → XP_005170345.1  SH3 and PX domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_005170345.1

    UniProtKB/TrEMBL
    A0A0R4IMX7, A0A8M2BHM1
    Related
    ENSDARP00000137221.1, ENSDART00000166936.2
    Conserved Domains (5) summary
    cd06888
    Location:6 → 124
    PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
    cd12018
    Location:823 → 878
    SH3_Tks4_4; Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12075
    Location:166 → 220
    SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12076
    Location:234 → 287
    SH3_Tks4_2; Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12078
    Location:371 → 423
    SH3_Tks4_3; Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains

  2. XM_021469251.2 → XP_021324926.1  SH3 and PX domain-containing protein 2B isoform X2

    UniProtKB/TrEMBL
    A0A8M9PRL0
    Conserved Domains (7) summary
    cd06888
    Location:6 → 124
    PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
    cd12018
    Location:822 → 877
    SH3_Tks4_4; Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12075
    Location:166 → 220
    SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12076
    Location:234 → 287
    SH3_Tks4_2; Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12078
    Location:370 → 422
    SH3_Tks4_3; Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    TIGR04211
    Location:252 → 325
    SH3_and_anchor; SH3 domain protein
    cl25526
    Location:605 → 680
    TonB_N; TonB N-terminal region

  3. XM_003200907.5 → XP_003200955.2  SH3 and PX domain-containing protein 2B isoform X3

    UniProtKB/TrEMBL
    A0A0R4IRP5, A0A8M1RMY5
    Related
    ENSDARP00000139646.1, ENSDART00000172135.2
    Conserved Domains (5) summary
    cd06888
    Location:6 → 124
    PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
    cd12018
    Location:811 → 866
    SH3_Tks4_4; Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12075
    Location:154 → 208
    SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12076
    Location:222 → 275
    SH3_Tks4_2; Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
    cd12078
    Location:359 → 411
    SH3_Tks4_3; Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains
Nucleotide Protein Strain
Heading Accession and Version

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