dchs1b dachsous cadherin-related 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dchs1bprovided by ZNC
Official Full Name: dachsous cadherin-related 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050208-41
See related: Ensembl:ENSDARG00000079850 AllianceGenome:ZFIN:ZDB-GENE-050208-41
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dchs1; pcdh16l; im:7136458; im:7156059
Summary: Predicted to enable cadherin binding activity and calcium ion binding activity. Acts upstream of or within several processes, including atrioventricular canal development; cortical granule exocytosis; and mitotic cleavage furrow formation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including blastomere; heart; mesoderm; musculature system; and retina. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (26269072..26430025, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (26307362..26368909, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis.
Title: Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis.
zebrafish Dchs1b is required for atrioventricular canal development
Title: Mutations in DCHS1 cause mitral valve prolapse.

Submit: New GeneRIF Correction

General gene information

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Markers

Z7504 (e-PCR)
- UniSTS:6683

fj29f10.y1 (e-PCR)
- UniSTS:198991

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular canal development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cortical granule exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within egg activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cleavage furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protocadherin-16

Names: dachsous 1; dachsous 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

26269072..26430025 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479350.2 → XP_021335025.2 protocadherin-16

Related

ENSDARP00000109139.2, ENSDART00000128894.4

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394786.1 Reference GRCz11 ALT_DRER_TU_1

Range

114262..274508 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021472280.2 → XP_021327955.1 protocadherin-16

UniProtKB/TrEMBL

A0A8M9Q3B3

Conserved Domains (1) summary

cd11304
Location:1123 → 1213

Cadherin_repeat; Cadherin tandem repeat domain