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cep135 centrosomal protein 135 [ Danio rerio (zebrafish) ]

Gene ID: 553303, updated on 12-Sep-2024

Summary

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Official Symbol
cep135provided by ZNC
Official Full Name
centrosomal protein 135provided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-325
See related
Ensembl:ENSDARG00000002991 AllianceGenome:ZFIN:ZDB-GENE-041210-325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkeyp-117h8.1
Summary
Predicted to act upstream of or within centriole replication and centriole-centriole cohesion. Predicted to be located in centriole. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8. Orthologous to human CEP135 (centrosomal protein 135). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See cep135 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (25711718..25735315)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (25812295..25836225)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 Neighboring gene transfer RNA cysteine (anticodon GCA)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring. Blanc M, et al. Sci Total Environ, 2021 Feb 1. PMID 32911150
  2. Genomic responses of DNA methylation and transcript profiles in zebrafish cells upon nutrient deprivation stress. Fan X, et al. Sci Total Environ, 2020 Jun 20. PMID 32208287
  3. Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. Sanchez NE, et al. G3 (Bethesda), 2017 Oct 5. PMID 28855284, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 135 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199990.1 → NP_001186919.1  centrosomal protein of 135 kDa

    See identical proteins and their annotated locations for NP_001186919.1

    Status: VALIDATED

    Source sequence(s)
    BX294157, CR352243
    UniProtKB/Swiss-Prot
    Q5RG45
    Related
    ENSDARP00000035272.7, ENSDART00000033436.9
    Conserved Domains (2) summary
    TIGR02168
    Location:202 → 963
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15290
    Location:291 → 407
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    25711718..25735315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160572.5 → XP_005160629.1  centrosomal protein of 135 kDa isoform X1

    See identical proteins and their annotated locations for XP_005160629.1

    UniProtKB/TrEMBL
    A0A8M2B7F9, F1R3P9
    Conserved Domains (2) summary
    TIGR02168
    Location:202 → 963
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15290
    Location:291 → 407
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  2. XM_005160573.5 → XP_005160630.1  centrosomal protein of 135 kDa isoform X1

    See identical proteins and their annotated locations for XP_005160630.1

    UniProtKB/TrEMBL
    A0A8M2B7F9, F1R3P9
    Conserved Domains (2) summary
    TIGR02168
    Location:202 → 963
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15290
    Location:291 → 407
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  3. XM_005160571.5 → XP_005160628.1  centrosomal protein of 135 kDa isoform X1

    See identical proteins and their annotated locations for XP_005160628.1

    UniProtKB/TrEMBL
    A0A8M2B7F9, F1R3P9
    Related
    ENSDARP00000107420.1, ENSDART00000121585.4
    Conserved Domains (2) summary
    TIGR02168
    Location:202 → 963
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15290
    Location:291 → 407
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  4. XM_009300714.4 → XP_009298989.1  centrosomal protein of 135 kDa isoform X2

    See identical proteins and their annotated locations for XP_009298989.1

    UniProtKB/Swiss-Prot
    Q5RG45
    Conserved Domains (2) summary
    TIGR02168
    Location:202 → 963
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15290
    Location:291 → 407
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RG45.2 GenPept UniProtKB/Swiss-Prot:Q5RG45

Gene LinkOut

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