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xrcc2 X-ray repair complementing defective repair in Chinese hamster cells 2 [ Danio rerio (zebrafish) ]

Gene ID: 553395, updated on 2-Nov-2024

Summary

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Official Symbol
xrcc2provided by ZNC
Official Full Name
X-ray repair complementing defective repair in Chinese hamster cells 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-121029-1
See related
Ensembl:ENSDARG00000013933 AllianceGenome:ZFIN:ZDB-GENE-121029-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable ATP binding activity; ATP-dependent DNA damage sensor activity; and DNA binding activity. Predicted to act upstream of or within double-strand break repair via homologous recombination. Predicted to be located in nucleus and replication fork. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group U; pancreatic cancer; primary ovarian insufficiency 17; and spermatogenic failure 50. Orthologous to human XRCC2 (X-ray repair cross complementing 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See xrcc2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (7322054..7330225)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (7295203..7300961)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene threonine synthase like 1 Neighboring gene dipeptidyl-peptidase 6a Neighboring gene sterile alpha motif domain-containing protein 3 Neighboring gene actin related protein 3B Neighboring gene lysine (K)-specific methyltransferase 2Ca Neighboring gene putative mediator of RNA polymerase II transcription subunit 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The cytotoxicity and genotoxicity of single and combined fenthion and terbufos treatments in human liver cells and zebrafish embryos. Wahyuni EA, et al. Sci Total Environ, 2021 Mar 1. PMID 33221015
  2. Combined exposure to nanoplastics and metal oxide nanoparticles inhibits efflux pumps and causes oxidative stress in zebrafish embryos. Bhagat J, et al. Sci Total Environ, 2022 Aug 20. PMID 35461948
  3. Selection of reliable biomarkers from PCR array analyses using relative distance computational model: methodology and proof-of-concept study. Liu C, et al. PLoS One, 2013. PMID 24349563, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in replication fork IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA repair protein XRCC2
Names
X-ray repair cross complementing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386478.1 → NP_001373407.1  DNA repair protein XRCC2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CU466274
    Related
    ENSDARP00000019152.6, ENSDART00000005804.7
    Conserved Domains (1) summary
    cd19490
    Location:53 → 273
    XRCC2; XRCC2 recombinase

  2. NM_001386479.1 → NP_001373408.1  DNA repair protein XRCC2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CU466274
    UniProtKB/TrEMBL
    A0A2R8QRN2, A0A8N7UUP4
    Related
    ENSDARP00000155837.1, ENSDART00000192873.1
    Conserved Domains (1) summary
    cd19490
    Location:41 → 261
    XRCC2; XRCC2 recombinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    7322054..7330225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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