sptbn1 spectrin, beta, non-erythrocytic 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sptbn1provided by ZNC
Official Full Name: spectrin, beta, non-erythrocytic 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-031006-3
See related: Ensembl:ENSDARG00000102883 AllianceGenome:ZFIN:ZDB-GENE-031006-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb30a06; fb92e08; wu:fb30a06; wu:fb92e08; si:zfos-1837d3.1
Summary: Predicted to enable actin binding activity and phospholipid binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in actin filament capping. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Predicted to be part of spectrin. Orthologous to human SPTBN1 (spectrin beta, non-erythrocytic 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (43132519..43226250, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (42840438..42933790, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb30a06.x1 (e-PCR)
- UniSTS:203099

fd05e09.y1 (e-PCR)
- UniSTS:194962

aa494795 (e-PCR)
- UniSTS:186821

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of spectrin	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spectrin beta chain, non-erythrocytic 1

Names: zmp:0000000587; zmp:0000000859

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365192.1 → NP_001352121.1 spectrin beta chain, non-erythrocytic 1

Status: VALIDATED

Source sequence(s)

CU655835, FO704577, FO834831, FP017152

Related

ENSDARP00000138563.1, ENSDART00000164700.2

Conserved Domains (4) summary

COG5069
Location:2 → 455

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:451 → 664

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2104 → 2209

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:1937 → 1995

Spectrin; Spectrin repeat