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snap29 synaptosome associated protein 29 [ Danio rerio (zebrafish) ]

Gene ID: 553460, updated on 2-Nov-2024

Summary

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Official Symbol
snap29provided by ZNC
Official Full Name
synaptosome associated protein 29provided by ZNC
Primary source
ZFIN:ZDB-GENE-041111-226
See related
Ensembl:ENSDARG00000038518 AllianceGenome:ZFIN:ZDB-GENE-041111-226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc84f09; im:7145101; wu:fc84f09; si:dkey-178e17.4
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Acts upstream of or within several processes, including epidermis morphogenesis; neuromuscular process; and pronephros morphogenesis. Predicted to be located in autophagosome membrane and ciliary membrane. Predicted to be part of SNARE complex. Predicted to be active in plasma membrane. Used to study CEDNIK syndrome. Human ortholog(s) of this gene implicated in CEDNIK syndrome. Orthologous to human SNAP29 (synaptosome associated protein 29). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See snap29 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (1839688..1856656)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (1834494..1846773)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene rasGAP-activating-like protein 1 Neighboring gene phosphatidylinositol 4-kinase, catalytic, alpha b Neighboring gene serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Neighboring gene si:dkey-178e17.3 Neighboring gene uncharacterized LOC137496286

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Li Q, et al. Dis Model Mech, 2011 Nov. PMID 21816950, Free PMC Article
  2. A genetic model of CEDNIK syndrome in zebrafish highlights the role of the SNARE protein Snap29 in neuromotor and epidermal development. Mastrodonato V, et al. Sci Rep, 2019 Feb 4. PMID 30718891, Free PMC Article
  3. Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. Lopez-Rivera E, et al. N Engl J Med, 2017 Feb 23. PMID 28121514, Free PMC Article
  4. Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. Guna A, et al. J Neurodev Disord, 2015. PMID 26137170, Free PMC Article
  5. Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation. Campbell PD, et al. Mol Psychiatry, 2023 Sep. PMID 37794116, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The morphological findings are akin to epidermal changes in harlequin ichthyosis and CEDNIK syndrome, autosomal recessive keratinization disorders due to mutations in the ABCA12 and SNAP29 genes, respectively.
    Title: Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromuscular process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephros morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pronephros morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synaptosomal-associated protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256256.1 → NP_001243185.1  synaptosomal-associated protein 29

    See identical proteins and their annotated locations for NP_001243185.1

    Status: VALIDATED

    Source sequence(s)
    CR788303
    UniProtKB/TrEMBL
    A0A8M1NZG6, F1Q5X0, F1QP00
    Related
    ENSDARP00000116213.1, ENSDART00000143473.3
    Conserved Domains (2) summary
    cd15856
    Location:206 → 263
    SNARE_SNAP29C; C-terminal SNARE motif of SNAP29
    cd15887
    Location:51 → 115
    SNARE_SNAP29N; N-terminal SNARE motif of SNAP29

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    1839688..1856656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166739.5 → XP_005166796.1  synaptosomal-associated protein 29 isoform X1

    See identical proteins and their annotated locations for XP_005166796.1

    UniProtKB/TrEMBL
    A0A8M1NZG6, F1Q5X0, F1QP00
    Related
    ENSDARP00000122078.1, ENSDART00000148254.3
    Conserved Domains (2) summary
    cd15856
    Location:206 → 263
    SNARE_SNAP29C; C-terminal SNARE motif of SNAP29
    cd15887
    Location:51 → 115
    SNARE_SNAP29N; N-terminal SNARE motif of SNAP29

  2. XM_005166738.5 → XP_005166795.1  synaptosomal-associated protein 29 isoform X1

    See identical proteins and their annotated locations for XP_005166795.1

    UniProtKB/TrEMBL
    A0A8M1NZG6, F1Q5X0, F1QP00
    Conserved Domains (2) summary
    cd15856
    Location:206 → 263
    SNARE_SNAP29C; C-terminal SNARE motif of SNAP29
    cd15887
    Location:51 → 115
    SNARE_SNAP29N; N-terminal SNARE motif of SNAP29
Nucleotide Protein
Heading Accession and Version

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