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mffb mitochondrial fission factor b [ Danio rerio (zebrafish) ]

Gene ID: 553588, updated on 2-Nov-2024

Summary

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Official Symbol
mffbprovided by ZNC
Official Full Name
mitochondrial fission factor bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-208
See related
Ensembl:ENSDARG00000039203 AllianceGenome:ZFIN:ZDB-GENE-050522-208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:5082098; zgc:110130
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in mitochondrial fission; positive regulation of mitochondrial fission; and protein targeting to mitochondrion. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial outer membrane and peroxisome. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See mffb in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (11651172..11662927, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (11867573..11879326, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909850 Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 2 Neighboring gene finTRIM family, member 1 Neighboring gene GREB1 like retinoic acid receptor coactivator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. Wen W, et al. PLoS One, 2023. PMID 38032938, Free PMC Article
  2. Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction. Sun CC, et al. FEBS J, 2023 Mar. PMID 36164851
  3. Insights Into the Peroxisomal Protein Inventory of Zebrafish. Kamoshita M, et al. Front Physiol, 2022. PMID 35295584, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC110130

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mitochondrial fission factor homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020566.2 → NP_001018402.2  mitochondrial fission factor homolog A

    See identical proteins and their annotated locations for NP_001018402.2

    Status: VALIDATED

    Source sequence(s)
    BC095179, EH441507, EH461639, EH581332
    UniProtKB/Swiss-Prot
    Q503U3
    UniProtKB/TrEMBL
    A0A8M2BIG1, A8E7S0
    Related
    ENSDARP00000120140.1, ENSDART00000145108.2
    Conserved Domains (1) summary
    pfam05644
    Location:12 → 286
    Miff; Mitochondrial and peroxisomal fission factor Mff

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    11651172..11662927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171167.4 → XP_005171224.1  mitochondrial fission factor homolog A isoform X1

    See identical proteins and their annotated locations for XP_005171224.1

    UniProtKB/Swiss-Prot
    Q503U3
    UniProtKB/TrEMBL
    A0A8M2BIG1, A8E7S0
    Conserved Domains (1) summary
    pfam05644
    Location:12 → 286
    Miff; Mitochondrial and peroxisomal fission factor Mff

  2. XM_005171168.5 → XP_005171225.1  mitochondrial fission factor homolog A isoform X1

    See identical proteins and their annotated locations for XP_005171225.1

    UniProtKB/Swiss-Prot
    Q503U3
    UniProtKB/TrEMBL
    A0A8M2BIG1, A8E7S0
    Conserved Domains (1) summary
    pfam05644
    Location:12 → 286
    Miff; Mitochondrial and peroxisomal fission factor Mff
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q503U3.1 GenPept UniProtKB/Swiss-Prot:Q503U3

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