U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

map3k7 mitogen-activated protein kinase kinase kinase 7 [ Danio rerio (zebrafish) ]

Gene ID: 553788, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
map3k7provided by ZNC
Official Full Name
mitogen-activated protein kinase kinase kinase 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-041001-135
See related
Ensembl:ENSDARG00000020469 AllianceGenome:ZFIN:ZDB-GENE-041001-135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TAK1b; zgc:110612; si:ch211-225h9.1
Summary
Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within blood vessel morphogenesis. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See map3k7 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (24151004..24183374, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (24251904..24284430, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene BTB and CNC homology 1, basic leucine zipper transcription factor 2b Neighboring gene uncharacterized LOC101886561 Neighboring gene transfer RNA proline (anticodon UGG) Neighboring gene transfer RNA serine (anticodon UGA)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX). Ouyang C, et al. J Biol Chem, 2014 Aug 29. PMID 25028512, Free PMC Article
  2. The TGF beta activated kinase TAK1 regulates vascular development in vivo. Jadrich JL, et al. Development, 2006 Apr. PMID 16556914
  3. Identification of multipath genes differentially expressed in pathway-targeted microarrays in zebrafish infected and surviving spring viremia carp virus (SVCV) suggest preventive drug candidates. Encinas P, et al. PLoS One, 2013. PMID 24069208, Free PMC Article
  4. The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Luo Q, et al. J Fish Biol, 2016 Apr. PMID 26992035
  5. Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Zhang CY, et al. Leukemia, 2018 Feb. PMID 28642593

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC110612

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mitogen-activated protein kinase kinase kinase 7
Names
TGF-beta-activated kinase TAK1
tak1
transforming growth factor beta-activated kinase 1b
NP_001018586.2
XP_009292938.1
XP_009292939.1
XP_068071544.1
XP_068071545.1
XP_068071546.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020750.2 → NP_001018586.2  mitogen-activated protein kinase kinase kinase 7

    Status: VALIDATED

    Source sequence(s)
    BX119992
    Related
    ENSDARP00000006286.8, ENSDART00000025862.11

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    24151004..24183374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215444.1 → XP_068071545.1  mitogen-activated protein kinase kinase kinase 7 isoform X3

  2. XM_009294664.4 → XP_009292939.1  mitogen-activated protein kinase kinase kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_009292939.1

    UniProtKB/TrEMBL
    A0A0R4IVJ5, A0A8M3AT57, Q503G7
    Conserved Domains (2) summary
    smart00219
    Location:25 → 273
    TyrKc; Tyrosine kinase, catalytic domain
    cd14058
    Location:31 → 281
    STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

  3. XM_009294663.4 → XP_009292938.1  mitogen-activated protein kinase kinase kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_009292938.1

    UniProtKB/TrEMBL
    A0A0R4IVJ5, A0A8M3AT57, Q503G7
    Related
    ENSDARP00000138323.1, ENSDART00000171184.3
    Conserved Domains (2) summary
    smart00219
    Location:25 → 273
    TyrKc; Tyrosine kinase, catalytic domain
    cd14058
    Location:31 → 281
    STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

  4. XM_068215445.1 → XP_068071546.1  mitogen-activated protein kinase kinase kinase 7 isoform X4

  5. XM_068215443.1 → XP_068071544.1  mitogen-activated protein kinase kinase kinase 7 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools