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uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) [ Danio rerio (zebrafish) ]

Gene ID: 554104, updated on 28-Oct-2024

Summary

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Official Symbol
uchl3provided by ZNC
Official Full Name
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-158
See related
Ensembl:ENSDARG00000030177 AllianceGenome:ZFIN:ZDB-GENE-050522-158
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:6908825; zgc:109963
Summary
Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within Notch signaling pathway and cranial skeletal system development. Predicted to be active in cytoplasm. Is expressed in notochord. Orthologous to human UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See uchl3 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21971319..21976635, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (22160591..22165766, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerisation domain containing 12.1 Neighboring gene LIM domain 7a Neighboring gene chromosome 9 C2orf80 homolog Neighboring gene shugoshin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR. Zhao S, et al. Proteomics, 2012 Jan. PMID 22140076
  2. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
  3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L3
NP_001019576.1
XP_068079487.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024405.1 → NP_001019576.1  ubiquitin carboxyl-terminal hydrolase isozyme L3

    See identical proteins and their annotated locations for NP_001019576.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095087
    UniProtKB/TrEMBL
    B2GPF3, F6NIR5, Q504C0
    Related
    ENSDARP00000095097.4, ENSDART00000104322.6
    Conserved Domains (1) summary
    cd09616
    Location:6 → 227
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    21971319..21976635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223386.1 → XP_068079487.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X1

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395278.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    340459..345634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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