fhl3b four and a half LIM domains 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fhl3bprovided by ZNC
Official Full Name: four and a half LIM domains 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8356
See related: Ensembl:ENSDARG00000104315 AllianceGenome:ZFIN:ZDB-GENE-030131-8356
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb09g09; zgc:63514; wu:fb09g09
Summary: Predicted to enable actin binding activity and transcription coregulator activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be active in Z disc; nucleus; and stress fiber. Orthologous to human FHL3 (four and a half LIM domains 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (4089494..4118394, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (4158668..4187555, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: four and a half LIM domains protein 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099978.1 → NP_001093448.1 four and a half LIM domains protein 3b

See identical proteins and their annotated locations for NP_001093448.1

Status: PROVISIONAL

Source sequence(s)

CR853286

UniProtKB/TrEMBL

A0A8M1NDX6, A5WUZ4

Related

ENSDARP00000131910.1, ENSDART00000169758.2

Conserved Domains (5) summary

cd09346
Location:162 → 213

LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)

cd09423
Location:36 → 94

LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)

cd09427
Location:98 → 155

LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)

cd09434
Location:221 → 276

LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

4089494..4118394 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173745.5 → XP_005173802.1 four and a half LIM domains protein 3b isoform X1

See identical proteins and their annotated locations for XP_005173802.1

UniProtKB/TrEMBL

A0A8M1NDX6, A5WUZ4

Conserved Domains (5) summary

cd09346
Location:162 → 213

LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)

cd09423
Location:36 → 94

LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)

cd09427
Location:98 → 155

LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)

cd09434
Location:221 → 276

LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers