shoc2 SHOC2 leucine rich repeat scaffold protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: shoc2provided by ZNC
Official Full Name: SHOC2 leucine rich repeat scaffold proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050208-523
See related: Ensembl:ENSDARG00000040853 AllianceGenome:ZFIN:ZDB-GENE-050208-523
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:152956; si:ch211-159c12.3; si:ch211-197i12.3
Summary: Predicted to enable protein phosphatase binding activity and volume-sensitive anion channel activity. Predicted to be involved in cyclic-GMP-AMP transmembrane import across plasma membrane; intracellular signal transduction; and positive regulation of Ras protein signal transduction. Predicted to be located in nucleus. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in cytoplasm. Used to study Noonan syndrome-like disorder with loose anagen hair and RASopathy. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 1 and atopic dermatitis. Orthologous to human SHOC2 (SHOC2 leucine rich repeat scaffold protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (29595294..29644460, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (29642796..29695436, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables volume-sensitive anion channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein phosphatase type 1 complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat protein SHOC-2

Names: protein soc-2 homolog; protein sur-8 homolog; soc-2 suppressor of clear homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044786.1 → NP_001038251.1 leucine-rich repeat protein SHOC-2

See identical proteins and their annotated locations for NP_001038251.1

Status: PROVISIONAL

Source sequence(s)

CR450802

UniProtKB/Swiss-Prot

A0JMD9, Q1L8Y7

Related

ENSDARP00000059881.4, ENSDART00000059882.5

Conserved Domains (3) summary

cd00116
Location:268 → 483

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:219 → 241

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:102 → 160

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

29595294..29644460 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005161796.5 → XP_005161853.1 leucine-rich repeat protein SHOC-2 isoform X1

See identical proteins and their annotated locations for XP_005161853.1

UniProtKB/Swiss-Prot

A0JMD9, Q1L8Y7

Conserved Domains (3) summary

cd00116
Location:268 → 483

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:219 → 241

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:102 → 160

LRR_8; Leucine rich repeat