m17 IL-6 subfamily cytokine M17 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: m17provided by ZNC
Official Full Name: IL-6 subfamily cytokine M17provided by ZNC
Primary source: ZFIN:ZDB-GENE-060526-368
See related: Ensembl:ENSDARG00000035435 AllianceGenome:ZFIN:ZDB-GENE-060526-368
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lif; si:dkeyp-15f12.5
Summary: Predicted to enable ciliary neurotrophic factor receptor binding activity; cytokine activity; and growth factor activity. Predicted to be involved in several processes, including astrocyte activation; cell surface receptor signaling pathway; and positive regulation of axon regeneration. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in membrane. Predicted to be active in axon; glial cell projection; and neuronal cell body. Is expressed in several structures, including brain; cranial ganglion; eye; pleuroperitoneal region; and presumptive neural retina. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (32155227..32158198, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (31555074..31558045, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIF is up-regulated during the early stage of optic nerve regeneration in zebrafish.
Title: Upregulation of leukemia inhibitory factor (LIF) during the early stage of optic nerve regeneration in zebrafish.
This protein and its receptors are involved in proper neural development in zebrafish.
Title: Analysis of leukemia inhibitory factor and leukemia inhibitory factor receptor in embryonic and adult zebrafish (Danio rerio).
The cDNA for zLIF encoded a predicted 215-amino acid protein with a putative 32-amino acid signal peptide, two disulfide bonds, and two N-linked glycosylation sites. Transcription of zlif starts at the hatching period during embryogenesis.[zLIF]
Title: Identification, cDNA cloning, and mRNA localization of a zebrafish ortholog of leukemia inhibitory factor.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ciliary neurotrophic factor receptor binding	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in astrocyte activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ciliary neurotrophic factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon regeneration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glial cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: IL-6 subfamily cytokine M17

Names: leukemia inhibitory factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.