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pdia5 protein disulfide isomerase family A, member 5 [ Danio rerio (zebrafish) ]

Gene ID: 556162, updated on 2-Nov-2024

Summary

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Official Symbol
pdia5provided by ZNC
Official Full Name
protein disulfide isomerase family A, member 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030521-5
See related
Ensembl:ENSDARG00000069242 AllianceGenome:ZFIN:ZDB-GENE-030521-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb441; wu:fb98h09; zgc:172235
Summary
Predicted to enable protein disulfide isomerase activity. Acts upstream of or within hemopoiesis. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alar plate midbrain region; anterior axial hypoblast; digestive system; fin; and nervous system. Orthologous to human PDIA5 (protein disulfide isomerase family A member 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See pdia5 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (37754845..37839334)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (37945050..38029539)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 49 member 4 Neighboring gene sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba Neighboring gene uncharacterized LOC137496490 Neighboring gene uncharacterized LOC137496491 Neighboring gene SEC22 homolog A, vesicle trafficking protein Neighboring gene adenylate cyclase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells. Chen YC, et al. PLoS One, 2012. PMID 22514630, Free PMC Article
  2. Stress-immune responses and DNA protection function of thioredoxin domain containing 12 in zebrafish (Danio rerio). Kulatunga DCM, et al. Fish Shellfish Immunol, 2019 Jan. PMID 30359749
  3. Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters. Vacca F, et al. J Physiol, 2022 May. PMID 35413133, Free PMC Article
  4. A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. Bielczyk-Maczyńska E, et al. PLoS Genet, 2014 Jul. PMID 25010335, Free PMC Article
  5. B cells in teleost fish act as pivotal initiating APCs in priming adaptive immunity: an evolutionary perspective on the origin of the B-1 cell subset and B7 molecules. Zhu LY, et al. J Immunol, 2014 Mar 15. PMID 24532580

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein disulfide-isomerase A5
NP_001107048.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113576.1 → NP_001107048.1  protein disulfide-isomerase A5 precursor

    Status: PROVISIONAL

    Source sequence(s)
    BC154606
    UniProtKB/TrEMBL
    A8WG75
    Related
    ENSDARP00000091365.4, ENSDART00000100592.5
    Conserved Domains (3) summary
    cd02997
    Location:407 → 510
    PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
    cd03067
    Location:36 → 147
    PDI_b_PDIR_N; PDIb family, PDIR subfamily, N-terminal TRX-like b domain; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. ...
    TIGR01130
    Location:181 → 512
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    37754845..37839334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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