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g3bp2a G3BP stress granule assembly factor 2a [ Danio rerio (zebrafish) ]

Gene ID: 556409, updated on 2-Nov-2024

Summary

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Official Symbol
g3bp2aprovided by ZNC
Official Full Name
G3BP stress granule assembly factor 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070112-1972
See related
Ensembl:ENSDARG00000014790 AllianceGenome:ZFIN:ZDB-GENE-070112-1972
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
g3bp2; fb43h08; fe25b02; wu:fb43h08; wu:fc13c01; wu:fe25b02; zgc:158370
Summary
Predicted to enable mRNA binding activity and molecular condensate scaffold activity. Predicted to be involved in stress granule assembly. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human G3BP2 (G3BP stress granule assembly factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See g3bp2a in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26334385..26465429)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (25751272..25771715)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4) Neighboring gene CXXC finger 4 Neighboring gene tet methylcytosine dioxygenase 2 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 38 Neighboring gene inorganic pyrophosphatase 2 Neighboring gene integrator complex subunit 12 Neighboring gene zinc finger CCHC domain-containing protein 18-like Neighboring gene USO1 vesicle transport factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Wu Y, et al. Sci Rep, 2017 Jun 22. PMID 28642470, Free PMC Article
  2. Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos. Lemeer S, et al. Mol Cell Proteomics, 2008 Nov. PMID 18550893
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular condensate scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein-binding protein 2
Names
GTPase activating protein (SH3 domain) binding protein 2
Ras-GTPase activating protein SH3 domain-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080563.1 → NP_001074032.1  ras GTPase-activating protein-binding protein 2

    See identical proteins and their annotated locations for NP_001074032.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129213
    UniProtKB/TrEMBL
    A0A8M1NCU4, A1L1U3
    Related
    ENSDARP00000046375.7, ENSDART00000046376.9
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cl17169
    Location:348 → 430
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    26334385..26465429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068219524.1 → XP_068075625.1  ras GTPase-activating protein-binding protein 2 isoform X1

    Related
    ENSDARP00000157047.1, ENSDART00000180810.1
Nucleotide Protein
Heading Accession and Version

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