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PRKACB protein kinase cAMP-activated catalytic subunit beta [ Homo sapiens (human) ]

Gene ID: 5567, updated on 3-Nov-2024

Summary

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Official Symbol
PRKACBprovided by HGNC
Official Full Name
protein kinase cAMP-activated catalytic subunit betaprovided by HGNC
Primary source
HGNC:HGNC:9381
See related
Ensembl:ENSG00000142875 MIM:176892; AllianceGenome:HGNC:9381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAFD2; PKACB; PKA C-beta
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]
Expression
Broad expression in brain (RPKM 61.5), colon (RPKM 21.8) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See PRKACB in Genome Data Viewer
Location:
1p31.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (84078079..84238498)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (83918534..84078964)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (84543762..84704181)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase like 7 Neighboring gene TTLL7 intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1013 Neighboring gene uncharacterized LOC124904205 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:84543332-84543857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1015 Neighboring gene TXN2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1016 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:84621187-84622386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1017 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:84689847-84690648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:84690649-84691448 Neighboring gene Sharpr-MPRA regulatory region 3408 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:84720292-84720890 Neighboring gene NANOG hESC enhancer GRCh37_chr1:84724969-84725470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1248 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene NEDD8 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Assignment of the gene encoding the catalytic subunit C beta of cAMP-dependent protein kinase to the p36 band on chromosome 1. Simard J, et al. Hum Genet, 1992 Mar. PMID 1551670
  2. Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness. Moen LV, et al. Urol Oncol, 2017 Mar. PMID 27838142
  3. The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo. Gamm DM, et al. J Biol Chem, 1996 Jun 28. PMID 8662989
  4. The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage. Rabbi MF, et al. Virology, 1998 Jun 5. PMID 9636365
  5. Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. Ørstavik S, et al. Eur J Biochem, 2001 Oct. PMID 11589697

See all (133) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual-Specificity Phosphatase 4 Promotes Malignant Features in Colorectal Cancer Through Cyclic-AMP Response Element Binding Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta Activation.
    Title: Dual-Specificity Phosphatase 4 Promotes Malignant Features in Colorectal Cancer Through Cyclic-AMP Response Element Binding Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta Activation.
  2. PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
    Title: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
  3. Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
    Title: Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
  4. Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.
    Title: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.
  5. Expressing MLH1 in HCT116 cells increases cellular resistance to radiation by activating the PRKAC.
    Title: Expressing MLH1 in HCT116 cells increases cellular resistance to radiation by activating the PRKAC.
  6. Novel implications of a strictly monomorphic (GCC) repeat in the human PRKACB gene.
    Title: Novel implications of a strictly monomorphic (GCC) repeat in the human PRKACB gene.
  7. The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.
    Title: The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.
  8. PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.
    Title: PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.
  9. Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.
    Title: Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.
  10. MicroRNA-384 Inhibits the Progression of Papillary Thyroid Cancer by Targeting PRKACB.
    Title: MicroRNA-384 Inhibits the Progression of Papillary Thyroid Cancer by Targeting PRKACB.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cardioacrofacial dysplasia 2
MedGen: C5436886 OMIM: 619143 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
env HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways PubMed
env The exposure of CD4+ T cells to HIV gp120 results in a long-lasting hyporesponsiveness to antigen stimulation through protein kinase A-mediated signaling PubMed
env Treatment of normal human fibroblasts with HIV-1 gp120 protein results in a significant decrease in the levels of 8-azido-[32P]cAMP binding to RI and RII domains of protein kinase A (PKA) and in PKA activity PubMed
Nef nef Serine residues Ser6 and Ser9 of HIV-1 Nef are phosphorylated by PKA in a cell-free system; intracellularly, only Ser9 of HIV-1 NL4-3 Nef is phosphorylated by PKA in resting peripheral blood mononuclear cells PubMed
Tat tat The binding between HIV-1 Tat and Grb2 is mediated by the proline-rich sequence (residues 1-18) of Tat and the SH3 domain (residues 160-212) of Grb2, which impairs activation of the Raf/MAPK pathway and increases the PKA/Raf inhibitory pathway PubMed
tat HIV-1 Tat-peptide(48-60) inhibits protein kinase C alpha and protein kinase A in a concentration-dependent manner PubMed
tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
capsid gag cAMP-dependent protein kinase is incorporated into HIV-1 virions, interacts with and phosphorylates the HIV-1 Capsid protein, and regulates HIV-1 infectivity PubMed
matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC9320, MGC41879, DKFZp586F2323, DKFZp781I2452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase activity TAS
Traceable Author Statement
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in high-density lipoprotein particle assembly TAS
Traceable Author Statement
more info
  
involved_in negative regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in renal water homeostasis TAS
Traceable Author Statement
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cAMP-dependent protein kinase complex TAS
Traceable Author Statement
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary base TAS
Traceable Author Statement
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase catalytic subunit beta
Names
protein kinase A catalytic subunit beta
protein kinase, cAMP-dependent, beta catalytic subunit
protein kinase, cAMP-dependent, catalytic, beta
NP_001229786.1
NP_001229787.1
NP_001229788.1
NP_001229789.1
NP_001229790.1
NP_001229791.1
NP_001287844.1
NP_001287845.1
NP_001287846.1
NP_001362489.1
NP_001362490.1
NP_001362491.1
NP_001362492.1
NP_001362493.1
NP_001362494.1
NP_001362498.1
NP_001362500.1
NP_001362501.1
NP_001362502.1
NP_001362503.1
NP_001362504.1
NP_001362505.1
NP_001362506.1
NP_001362507.1
NP_001362508.1
NP_001362509.1
NP_001362510.1
NP_002722.1
NP_891993.1
NP_997461.1
XP_005271077.1
XP_016857200.1
XP_016857205.1
XP_016857206.1
XP_047280637.1
XP_054193534.1
XP_054193535.1
XP_054193536.1
XP_054193537.1
XP_054193538.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029728.1 RefSeqGene

    Range
    71210..165437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242857.3 → NP_001229786.1  cAMP-dependent protein kinase catalytic subunit beta isoform 4

    See identical proteins and their annotated locations for NP_001229786.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' exon structure, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK296482, AL450063, BX641026, DC322547
    Consensus CDS
    CCDS55609.1
    UniProtKB/TrEMBL
    A8K8B9
    Related
    ENSP00000401252.2, ENST00000446538.5
    Conserved Domains (1) summary
    cd14209
    Location:49 → 338
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  2. NM_001242858.3 → NP_001229787.1  cAMP-dependent protein kinase catalytic subunit beta isoform 5

    See identical proteins and their annotated locations for NP_001229787.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' exon structure, compared to variant 1. The encoded isoform (5, also known as Cbeta3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK304375, AL450063, BX641026, DC322547
    Consensus CDS
    CCDS72813.1
    UniProtKB/TrEMBL
    A8K8B9
    Related
    ENSP00000481980.1, ENST00000610703.4
    Conserved Domains (1) summary
    cd14209
    Location:30 → 319
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  3. NM_001242859.3 → NP_001229788.1  cAMP-dependent protein kinase catalytic subunit beta isoform 6

    See identical proteins and their annotated locations for NP_001229788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' exon structure, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL450063, BX641026
    Consensus CDS
    CCDS55610.1
    UniProtKB/TrEMBL
    A8K8B9
    Related
    ENSP00000390906.2, ENST00000436133.6
    Conserved Domains (1) summary
    cd14209
    Location:46 → 335
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  4. NM_001242860.3 → NP_001229789.1  cAMP-dependent protein kinase catalytic subunit beta isoform 7

    See identical proteins and their annotated locations for NP_001229789.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' exon structure, compared to variant 1. The encoded isoform (7, also known as Cbeta4abc) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB209189, AL450063, BX641026, DA188681
    Consensus CDS
    CCDS72815.1
    UniProtKB/TrEMBL
    A8K8B9
    Related
    ENSP00000479722.1, ENST00000614872.4
    Conserved Domains (1) summary
    cd14209
    Location:48 → 337
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  5. NM_001242861.3 → NP_001229790.1  cAMP-dependent protein kinase catalytic subunit beta isoform 8

    See identical proteins and their annotated locations for NP_001229790.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' exon structure, compared to variant 1. The encoded isoform (8, also known as Cbeta4ab) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK091420, AL450063, BX641026, DA188681
    Consensus CDS
    CCDS55611.1
    UniProtKB/TrEMBL
    A8K8B9
    Related
    ENSP00000378315.2, ENST00000394839.6
    Conserved Domains (1) summary
    cd14209
    Location:45 → 301
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  6. NM_001242862.3 → NP_001229791.1  cAMP-dependent protein kinase catalytic subunit beta isoform 9

    See identical proteins and their annotated locations for NP_001229791.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' exon structure, compared to variant 1. The encoded isoform (9) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK316115, AL450063, BX641026, DA228647
    Consensus CDS
    CCDS72816.1
    UniProtKB/TrEMBL
    A0A087WVC4, B7ZA00
    Related
    ENSP00000479339.1, ENST00000610457.2
    Conserved Domains (1) summary
    cd14209
    Location:29 → 318
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  7. NM_001300915.2 → NP_001287844.1  cAMP-dependent protein kinase catalytic subunit beta isoform 10

    See identical proteins and their annotated locations for NP_001287844.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in both the 5' and 3' exon structures, compared to variant 1. The encoded isoform (10) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AA761973, BC016285, BX369882, BX647515, DA188681
    Consensus CDS
    CCDS72814.1
    UniProtKB/TrEMBL
    B1APG3
    Related
    ENSP00000359714.1, ENST00000370680.5
    Conserved Domains (1) summary
    cl21453
    Location:48 → 264
    PKc_like; Protein Kinases, catalytic domain

  8. NM_001300916.2 → NP_001287845.1  cAMP-dependent protein kinase catalytic subunit beta isoform 11

    See identical proteins and their annotated locations for NP_001287845.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 3' exon structure, compared to variant 1. The encoded isoform (11) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA761973, BC016285, BM905428, BX369882, DC418574
    UniProtKB/Swiss-Prot
    P22694
    Conserved Domains (1) summary
    cl21453
    Location:89 → 302
    PKc_like; Protein Kinases, catalytic domain

  9. NM_001300917.2 → NP_001287846.1  cAMP-dependent protein kinase catalytic subunit beta isoform 12

    See identical proteins and their annotated locations for NP_001287846.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in both the 5' and 3' exon structures, compared to variant 1. The encoded isoform (12) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AA761973, BC016285, BI598037, BX369882, DC322547
    Consensus CDS
    CCDS72812.1
    UniProtKB/TrEMBL
    B1APF8, B1APF9
    Related
    ENSP00000359718.1, ENST00000370684.5
    Conserved Domains (1) summary
    cl21453
    Location:30 → 243
    PKc_like; Protein Kinases, catalytic domain

  10. NM_001375560.1 → NP_001362489.1  cAMP-dependent protein kinase catalytic subunit beta isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    A8K8B9
    Conserved Domains (1) summary
    cd14209
    Location:45 → 334
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  11. NM_001375561.1 → NP_001362490.1  cAMP-dependent protein kinase catalytic subunit beta isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    A8K8B9
    Conserved Domains (1) summary
    cd14209
    Location:40 → 329
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  12. NM_001375562.1 → NP_001362491.1  cAMP-dependent protein kinase catalytic subunit beta isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    A8K8B9
    Conserved Domains (1) summary
    cd14209
    Location:41 → 330
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  13. NM_001375563.1 → NP_001362492.1  cAMP-dependent protein kinase catalytic subunit beta isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    A8K8B9
    Conserved Domains (1) summary
    cd14209
    Location:38 → 327
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  14. NM_001375564.1 → NP_001362493.1  cAMP-dependent protein kinase catalytic subunit beta isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    A8K8B9
    Conserved Domains (1) summary
    cd14209
    Location:37 → 326
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  15. NM_001375565.1 → NP_001362494.1  cAMP-dependent protein kinase catalytic subunit beta isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    A8K8B9
    Conserved Domains (1) summary
    cd14209
    Location:29 → 318
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  16. NM_001375569.1 → NP_001362498.1  cAMP-dependent protein kinase catalytic subunit beta isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:49 → 262
    PKc_like; Protein Kinases, catalytic domain

  17. NM_001375571.1 → NP_001362500.1  cAMP-dependent protein kinase catalytic subunit beta isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:48 → 261
    PKc_like; Protein Kinases, catalytic domain

  18. NM_001375572.1 → NP_001362501.1  cAMP-dependent protein kinase catalytic subunit beta isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    B1APF8
    Conserved Domains (1) summary
    cl21453
    Location:46 → 262
    PKc_like; Protein Kinases, catalytic domain

  19. NM_001375573.1 → NP_001362502.1  cAMP-dependent protein kinase catalytic subunit beta isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    B1APF8
    Conserved Domains (1) summary
    cl21453
    Location:45 → 261
    PKc_like; Protein Kinases, catalytic domain

  20. NM_001375574.1 → NP_001362503.1  cAMP-dependent protein kinase catalytic subunit beta isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    B1APG2
    Conserved Domains (1) summary
    cl21453
    Location:40 → 256
    PKc_like; Protein Kinases, catalytic domain

  21. NM_001375575.1 → NP_001362504.1  cAMP-dependent protein kinase catalytic subunit beta isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    B1APG2
    Conserved Domains (1) summary
    cl21453
    Location:45 → 258
    PKc_like; Protein Kinases, catalytic domain

  22. NM_001375576.1 → NP_001362505.1  cAMP-dependent protein kinase catalytic subunit beta isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL359504, AL450063
    UniProtKB/TrEMBL
    K7ERP6
    Conserved Domains (1) summary
    cl21453
    Location:42 → 258
    PKc_like; Protein Kinases, catalytic domain

  23. NM_001375577.1 → NP_001362506.1  cAMP-dependent protein kinase catalytic subunit beta isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    B1APG2
    Conserved Domains (1) summary
    cl21453
    Location:40 → 253
    PKc_like; Protein Kinases, catalytic domain

  24. NM_001375578.1 → NP_001362507.1  cAMP-dependent protein kinase catalytic subunit beta isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    B1APF8
    Conserved Domains (1) summary
    cl21453
    Location:30 → 246
    PKc_like; Protein Kinases, catalytic domain

  25. NM_001375579.1 → NP_001362508.1  cAMP-dependent protein kinase catalytic subunit beta isforom 29

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    B1APG1
    Conserved Domains (1) summary
    cl21453
    Location:29 → 245
    PKc_like; Protein Kinases, catalytic domain

  26. NM_001375580.1 → NP_001362509.1  cAMP-dependent protein kinase catalytic subunit beta isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL450063
    UniProtKB/TrEMBL
    B1APG1
    Related
    ENSP00000399326.1, ENST00000417530.5
    Conserved Domains (1) summary
    cl21453
    Location:29 → 242
    PKc_like; Protein Kinases, catalytic domain

  27. NM_001375581.1 → NP_001362510.1  cAMP-dependent protein kinase catalytic subunit beta isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL450063
    Conserved Domains (1) summary
    cl21453
    Location:49 → 265
    PKc_like; Protein Kinases, catalytic domain

  28. NM_002731.4 → NP_002722.1  cAMP-dependent protein kinase catalytic subunit beta isoform 2

    See identical proteins and their annotated locations for NP_002722.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' exon structure, compared to variant 1. The encoded isoform (2, also known as Cbeta1) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC035058, BX537705, BX641026, HY160843, M34181
    Consensus CDS
    CCDS691.1
    UniProtKB/Swiss-Prot
    B1APG4, B4DKB0, B4E2Q1, P22694, Q14VH1, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0, Q96B09
    UniProtKB/TrEMBL
    A8K8B9, B2RB89, D3DT10
    Related
    ENSP00000359723.2, ENST00000370689.6
    Conserved Domains (1) summary
    cd14209
    Location:42 → 331
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  29. NM_182948.4 → NP_891993.1  cAMP-dependent protein kinase catalytic subunit beta isoform 1

    See identical proteins and their annotated locations for NP_891993.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Cbeta2).
    Source sequence(s)
    BC035058, BX485407, BX537705, BX641026, M34181
    Consensus CDS
    CCDS693.1
    UniProtKB/TrEMBL
    B4E2L0
    Related
    ENSP00000359719.3, ENST00000370685.7
    Conserved Domains (1) summary
    cd14209
    Location:89 → 378
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  30. NM_207578.3 → NP_997461.1  cAMP-dependent protein kinase catalytic subunit beta isoform 3

    See identical proteins and their annotated locations for NP_997461.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in both the 5' and 3' exon structures, compared to variant 1. The encoded isoform (3) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AA761973, BC016285, BX369882, HY160843
    Consensus CDS
    CCDS692.1
    UniProtKB/TrEMBL
    K7ERP6
    Related
    ENSP00000359722.3, ENST00000370688.7
    Conserved Domains (1) summary
    cl21453
    Location:42 → 255
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    84078079..84238498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271020.3 → XP_005271077.1  cAMP-dependent protein kinase catalytic subunit beta isoform X1

    See identical proteins and their annotated locations for XP_005271077.1

    Conserved Domains (1) summary
    cl21453
    Location:89 → 305
    PKc_like; Protein Kinases, catalytic domain

  2. XM_047424681.1 → XP_047280637.1  cAMP-dependent protein kinase catalytic subunit beta isoform X2

  3. XM_017001711.2 → XP_016857200.1  cAMP-dependent protein kinase catalytic subunit beta isoform X3

    UniProtKB/TrEMBL
    B1APF8
    Conserved Domains (1) summary
    cl21453
    Location:46 → 259
    PKc_like; Protein Kinases, catalytic domain

  4. XM_017001716.2 → XP_016857205.1  cAMP-dependent protein kinase catalytic subunit beta isoform X4

    UniProtKB/TrEMBL
    B1APF8
    Related
    ENSP00000392275.1, ENST00000432111.5

  5. XM_017001717.2 → XP_016857206.1  cAMP-dependent protein kinase catalytic subunit beta isoform X5

    UniProtKB/TrEMBL
    B1APG2
    Related
    ENSP00000397175.1, ENST00000413538.5

RNA

  1. XR_007061945.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    83918534..84078964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337559.1 → XP_054193534.1  cAMP-dependent protein kinase catalytic subunit beta isoform X1

  2. XM_054337560.1 → XP_054193535.1  cAMP-dependent protein kinase catalytic subunit beta isoform X2

  3. XM_054337561.1 → XP_054193536.1  cAMP-dependent protein kinase catalytic subunit beta isoform X3

  4. XM_054337562.1 → XP_054193537.1  cAMP-dependent protein kinase catalytic subunit beta isoform X4

  5. XM_054337563.1 → XP_054193538.1  cAMP-dependent protein kinase catalytic subunit beta isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22694.2 GenPept UniProtKB/Swiss-Prot:P22694

Gene LinkOut

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