add3a adducin 3 (gamma) a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: add3aprovided by ZNC
Official Full Name: adducin 3 (gamma) aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2721
See related: Ensembl:ENSDARG00000040874 AllianceGenome:ZFIN:ZDB-GENE-030131-2721
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: add3; zgc:55560; zgc:55992; zgc:77226; wu:fb38g03; wu:fc16e06
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within hepaticobiliary system development. Predicted to be active in cytoskeleton; plasma membrane; and postsynaptic density. Is expressed in head; liver; pericardial region; and pleuroperitoneal region. Used to study biliary atresia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human ADD3 (adducin 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (30047244..30272399)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (30098041..30323200)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

add3a may be affecting the Hh pathway, an important factor in BA pathogenesis.
Title: Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish.
Knockdown of miR-143 or disruption of the miR-143-add3 interaction inhibits ventricular cardiomyocyte F-actin remodeling, which blocks their normal growth and elongation and leads to ventricular collapse and decreased contractility.
Title: The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis.

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General gene information

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Markers

G41692 (e-PCR)
- UniSTS:37407

fb09e09.y1 (e-PCR)
- UniSTS:189983

fc16e06.x1 (e-PCR)
- UniSTS:203830

fb30h05.x1 (e-PCR)
- UniSTS:203106

fb38g03.x1 (e-PCR)
- UniSTS:203178

fi35c02.x1 (e-PCR)
- UniSTS:197363

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hepaticobiliary system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adducin 3 (gamma) a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199663.1 → NP_955957.1 adducin 3 (gamma) a

See identical proteins and their annotated locations for NP_955957.1

Status: PROVISIONAL

Source sequence(s)

BC050486

UniProtKB/TrEMBL

Q7ZUA1

Related

ENSDARP00000040537.6, ENSDART00000040538.8

Conserved Domains (1) summary

cl00214
Location:134 → 382

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

30047244..30272399

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021469329.2 → XP_021325004.1 adducin 3 (gamma) a isoform X1

UniProtKB/TrEMBL

A0A2R8Q5P5, A0A8M6Z3D4

Conserved Domains (1) summary

cl00214
Location:134 → 382

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_021469331.2 → XP_021325006.1 adducin 3 (gamma) a isoform X3

UniProtKB/TrEMBL

A0A0R4IBJ3, A0A8M2B8L7, Q1LUP1

Conserved Domains (1) summary

cl00214
Location:134 → 382

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_068216304.1 → XP_068072405.1 adducin 3 (gamma) a isoform X4
XM_068216306.1 → XP_068072407.1 adducin 3 (gamma) a isoform X6
XM_017353147.3 → XP_017208636.1 adducin 3 (gamma) a isoform X1

UniProtKB/TrEMBL

A0A2R8Q5P5, A0A8M6Z3D4

Related

ENSDARP00000151475.1, ENSDART00000192546.1

Conserved Domains (1) summary

cl00214
Location:134 → 382

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_068216303.1 → XP_068072404.1 adducin 3 (gamma) a isoform X3
XM_068216305.1 → XP_068072406.1 adducin 3 (gamma) a isoform X4

Related

ENSDARP00000150354.1, ENSDART00000185369.1
XM_068216302.1 → XP_068072403.1 adducin 3 (gamma) a isoform X1
XM_017353148.3 → XP_017208637.1 adducin 3 (gamma) a isoform X1

UniProtKB/TrEMBL

A0A2R8Q5P5, A0A8M6Z3D4

Related

ENSDARP00000146315.1, ENSDART00000187808.1

Conserved Domains (1) summary

cl00214
Location:134 → 382

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_017353146.3 → XP_017208635.1 adducin 3 (gamma) a isoform X1

UniProtKB/TrEMBL

A0A2R8Q5P5, A0A8M6Z3D4

Conserved Domains (1) summary

cl00214
Location:134 → 382

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_017353149.3 → XP_017208638.1 adducin 3 (gamma) a isoform X2

UniProtKB/TrEMBL

A0A8M6YXA3
XM_017353150.3 → XP_017208639.1 adducin 3 (gamma) a isoform X5

UniProtKB/TrEMBL

A0A8M6Z434
XM_005161804.5 → XP_005161861.1 adducin 3 (gamma) a isoform X3

See identical proteins and their annotated locations for XP_005161861.1

UniProtKB/TrEMBL

A0A0R4IBJ3, A0A8M2B8L7, Q1LUP1

Conserved Domains (1) summary

cl00214
Location:134 → 382

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_005161805.5 → XP_005161862.1 adducin 3 (gamma) a isoform X4

UniProtKB/TrEMBL

A0A2R8QBF8, A0A8M2B8P9

Conserved Domains (1) summary

cl00214
Location:134 → 382

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_005161807.5 → XP_005161864.1 adducin 3 (gamma) a isoform X6

UniProtKB/TrEMBL

A0A8M2B8Q9, F1R6L1, Q1LUP2

Related

ENSDARP00000049074.6, ENSDART00000049075.8

Conserved Domains (1) summary

cl00214
Location:134 → 382

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...