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sash1a SAM and SH3 domain containing 1a [ Danio rerio (zebrafish) ]

Gene ID: 557132, updated on 28-Oct-2024

Summary

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Official Symbol
sash1aprovided by ZNC
Official Full Name
SAM and SH3 domain containing 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9960
See related
Ensembl:ENSDARG00000007179 AllianceGenome:ZFIN:ZDB-GENE-030131-9960
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi33a01; tdsubc_2e1; wu:fi33a01; ik:tdsubc_2e1; xx:tdsubc_2e1; si:dkey-264g21.1
Summary
Predicted to be involved in positive regulation of non-canonical NF-kappaB signal transduction. Is expressed in forebrain; hindbrain; and midbrain. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human SASH1 (SAM and SH3 domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See sash1a in Genome Data Viewer
Location:
chromosome: 20
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (31430186..31744462, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (31527307..31594421, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 16 Neighboring gene uncharacterized LOC137488589 Neighboring gene uronyl 2-sulfotransferase a Neighboring gene uncharacterized LOC137488662 Neighboring gene syntaxin binding protein 5a (tomosyn) Neighboring gene androglobin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. SASH1 contributes to glial cell migration in the early development of the central nervous system. Zhou Z, et al. Dev Biol, 2023 Dec. PMID 37741309
  2. Hyperactivity, Memory Defects, and Craniofacial Abnormalities in Zebrafish fmr1 Mutant Larvae. Hu J, et al. Behav Genet, 2020 May. PMID 32048109
  3. Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. Shamay-Ramot A, et al. PLoS Genet, 2015 Dec. PMID 26637167, Free PMC Article
  4. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SASH1 contributes to glial cell migration in the early development of the central nervous system.
    Title: SASH1 contributes to glial cell migration in the early development of the central nervous system.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC162728

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in positive regulation of non-canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SAM and SH3 domain-containing protein 1a
Names
SAM and SH3 domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044819.1 → NP_001038284.1  SAM and SH3 domain-containing protein 1a

    See identical proteins and their annotated locations for NP_001038284.1

    Status: PROVISIONAL

    Source sequence(s)
    BX511140
    UniProtKB/TrEMBL
    A0A8M9PSQ8, B7ZVJ8, Q5TZ33
    Related
    ENSDARP00000046840.6, ENSDART00000046841.9
    Conserved Domains (4) summary
    smart00454
    Location:628 → 692
    SAM; Sterile alpha motif
    cd11967
    Location:552 → 608
    SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
    pfam12485
    Location:400 → 550
    SLY; Lymphocyte signaling adaptor protein
    cl15755
    Location:628 → 693
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    31430186..31744462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215463.1 → XP_068071564.1  SAM and SH3 domain-containing protein 1a isoform X7

  2. XM_021468433.2 → XP_021324108.1  SAM and SH3 domain-containing protein 1a isoform X3

    UniProtKB/TrEMBL
    A0A8M9PBR7, A0A8M9PPC5
    Conserved Domains (5) summary
    cd09559
    Location:807 → 872
    SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
    cd11967
    Location:731 → 787
    SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
    pfam12485
    Location:582 → 729
    SLY; Lymphocyte signaling adaptor protein
    cl15755
    Location:1309 → 1367
    SAM_superfamily; SAM (Sterile alpha motif )
    cl26464
    Location:1076 → 1197
    Atrophin-1; Atrophin-1 family

  3. XM_021468436.2 → XP_021324111.1  SAM and SH3 domain-containing protein 1a isoform X6

    UniProtKB/TrEMBL
    A0A8M9P2L4, A0A8M9PPD1
    Conserved Domains (5) summary
    cd09492
    Location:1242 → 1300
    SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
    cd09559
    Location:740 → 805
    SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
    cd11967
    Location:664 → 720
    SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
    pfam12485
    Location:515 → 662
    SLY; Lymphocyte signaling adaptor protein
    cl26464
    Location:1009 → 1130
    Atrophin-1; Atrophin-1 family

  4. XM_021468434.2 → XP_021324109.1  SAM and SH3 domain-containing protein 1a isoform X4

    UniProtKB/TrEMBL
    A0A8M9PHC0, A0A8M9PPC5
    Conserved Domains (5) summary
    cd09492
    Location:1276 → 1334
    SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
    cd09559
    Location:774 → 839
    SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
    cd11967
    Location:698 → 754
    SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
    pfam12485
    Location:549 → 696
    SLY; Lymphocyte signaling adaptor protein
    cl26464
    Location:1043 → 1164
    Atrophin-1; Atrophin-1 family
Nucleotide Protein
Heading Accession and Version

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