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mdm1 Mdm1 nuclear protein [ Danio rerio (zebrafish) ]

Gene ID: 557148, updated on 2-Nov-2024

Summary

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Official Symbol
mdm1provided by ZNC
Official Full Name
Mdm1 nuclear proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-117
See related
Ensembl:ENSDARG00000045675 AllianceGenome:ZFIN:ZDB-GENE-041210-117
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-266a5.6
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in negative regulation of centriole replication. Predicted to be located in centriole; centrosome; and nucleus. Is expressed in brain; neural tube; pronephric duct; and tail bud. Orthologous to human MDM1 (Mdm1 nuclear protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mdm1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (13551126..13567530, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (13552215..13568667, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene interleukin 26 Neighboring gene interleukin 22 Neighboring gene calumenin a Neighboring gene opsin 1 (cone pigments), short-wave-sensitive 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. In vitro characterization of grass carp (Ctenopharyngodon idella) IL-26 in regulating inflammatory factors. Qiu X, et al. Fish Shellfish Immunol, 2017 Jul. PMID 28495510
  2. An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and -26 from teleost: IL-22 and -26 genes have been described for the first time outside mammals. Igawa D, et al. Mol Immunol, 2006 Mar. PMID 16005068
  3. Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates. Hensley MR, et al. PLoS One, 2016. PMID 27658201, Free PMC Article
  4. Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish. Lam SH, et al. PLoS One, 2011. PMID 22194820, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of centriole replication IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of centriole replication ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nuclear protein MDM1
Names
Mdm1 nuclear protein homolog
Mdm4, transformed 3T3 cell double minute 1, p53 binding protein, homolog
transformed 3T3 cell double minute 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044820.1 → NP_001038285.1  nuclear protein MDM1

    See identical proteins and their annotated locations for NP_001038285.1

    Status: PROVISIONAL

    Source sequence(s)
    BX465210
    UniProtKB/Swiss-Prot
    A3KNZ6, Q5RHU7, Q5RHU8
    Related
    ENSDARP00000092786.4, ENSDART00000102010.6
    Conserved Domains (1) summary
    pfam15501
    Location:9 → 510
    MDM1; Nuclear protein MDM1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    13551126..13567530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068219645.1 → XP_068075746.1  nuclear protein MDM1 isoform X2

  2. XM_009300141.4 → XP_009298416.1  nuclear protein MDM1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AYM1
    Conserved Domains (1) summary
    pfam15501
    Location:9 → 523
    MDM1; Nuclear protein MDM1

  3. XM_009300143.4 → XP_009298418.1  nuclear protein MDM1 isoform X5

    UniProtKB/TrEMBL
    A0A8M3B8U5, Z4YIK0
    Related
    ENSDARP00000116078.2, ENSDART00000132971.4
    Conserved Domains (1) summary
    pfam15501
    Location:9 → 521
    MDM1; Nuclear protein MDM1

  4. XM_005164639.5 → XP_005164696.1  nuclear protein MDM1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BBV3
    Conserved Domains (1) summary
    pfam15501
    Location:9 → 534
    MDM1; Nuclear protein MDM1

  5. XM_068219646.1 → XP_068075747.1  nuclear protein MDM1 isoform X6

  6. XM_009300142.4 → XP_009298417.1  nuclear protein MDM1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3AR99
    Conserved Domains (1) summary
    pfam15501
    Location:4 → 504
    MDM1; Nuclear protein MDM1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RHU7.1 GenPept UniProtKB/Swiss-Prot:Q5RHU7

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