nlrx1 NLR family member X1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nlrx1provided by ZNC
Official Full Name: NLR family member X1provided by ZNC
Primary source: ZFIN:ZDB-GENE-071119-3
See related: Ensembl:ENSDARG00000073724 AllianceGenome:ZFIN:ZDB-GENE-071119-3
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to be involved in intracellular signal transduction and negative regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be active in mitochondrion. Orthologous to human NLRX1 (NLR family member X1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (23468025..23485738, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (23532760..23550511, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING.
Title: A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in negative regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NLR family member X1

Names: NLR-A5; Nod5; Nod9

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

23468025..23485738 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466415.2 → XP_021322090.1 NLR family member X1 isoform X2

UniProtKB/TrEMBL

A0A8M9PLL8

Conserved Domains (3) summary

sd00033
Location:748 → 775

LRR_RI; leucine-rich repeat [structural motif]

cl21455
Location:179 → 338

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl26161
Location:646 → 869

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_680389.10 → XP_685481.4 NLR family member X1 isoform X1

See identical proteins and their annotated locations for XP_685481.4

UniProtKB/TrEMBL

A0A8M9PCD5, E7FDW7

Related

ENSDARP00000126680.1, ENSDART00000152706.3

Conserved Domains (4) summary

sd00033
Location:717 → 740

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:748 → 777

LRR_AMN1; leucine-rich repeat [structural motif]

cl21455
Location:179 → 338

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl26161
Location:664 → 904

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_021466414.2 → XP_021322089.1 NLR family member X1 isoform X1

UniProtKB/TrEMBL

A0A8M9PCD5, E7FDW7

Related

ENSDARP00000154296.1, ENSDART00000185523.1

Conserved Domains (4) summary

sd00033
Location:717 → 740

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:748 → 777

LRR_AMN1; leucine-rich repeat [structural motif]

cl21455
Location:179 → 338

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl26161
Location:664 → 904

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...