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cfi complement factor I [ Danio rerio (zebrafish) ]

Gene ID: 557557, updated on 2-Nov-2024

Summary

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Official Symbol
cfiprovided by ZNC
Official Full Name
complement factor Iprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110922-7
See related
AllianceGenome:ZFIN:ZDB-GENE-110922-7
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gb:ai721528
Summary
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within retinal blood vessel morphogenesis. Predicted to be located in extracellular region and membrane. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; age related macular degeneration 13; atypical hemolytic-uremic syndrome; complement factor I deficiency; and macular degeneration. Orthologous to human CFI (complement factor I). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See cfi in Genome Data Viewer
Location:
chromosome: 23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (45276998..45300481)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003336537.1 (14444..42415)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene PC4 and SFRS1 interacting protein 1b Neighboring gene tetratricopeptide repeat domain 39B Neighboring gene sphingomyelin synthase 2b Neighboring gene coiled-coil domain containing 171 Neighboring gene axoneme-associated protein mst101(2)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration. Tan PL, et al. Invest Ophthalmol Vis Sci, 2017 Mar 1. PMID 28282489, Free PMC Article
  2. A functional variant in the CFI gene confers a high risk of age-related macular degeneration. van de Ven JP, et al. Nat Genet, 2013 Jul. PMID 23685748
  3. Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Li L, et al. Mol Immunol, 2020 Dec. PMID 33160183
  4. Ypel5 regulates liver development and function in zebrafish. Deng Y, et al. J Mol Cell Biol, 2023 Aug 3. PMID 36948605, Free PMC Article
  5. Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. Lam SH, et al. BMC Med Genomics, 2011 May 16. PMID 21575170, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retinal blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement factor I
XP_017209949.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    45276998..45300481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354460.3 → XP_017209949.2  complement factor I

Nucleotide Protein Strain
Heading Accession and Version

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Research Materials