ak9 adenylate kinase 9 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ak9provided by ZNC
Official Full Name: adenylate kinase 9provided by ZNC
Primary source: ZFIN:ZDB-GENE-041014-337
See related: Ensembl:ENSDARG00000021913 AllianceGenome:ZFIN:ZDB-GENE-041014-337
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: akd1; si:ch211-199m3.2
Summary: Predicted to enable (d)CMP kinase activity and UMP kinase activity. Acts upstream of or within cilium movement. Located in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 89. Orthologous to human AK9 (adenylate kinase 9). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (33708318..33737844)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (33805434..33834944)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fj28b07.y1 (e-PCR)
- UniSTS:198952

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables (d)CMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables UMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleobase-containing compound kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adenylate kinase domain-containing protein 1; adenylate kinase 9

Names: adenylate kinase domain containing 1

XP_068071756.1

EC 2.7.4.3

XP_685909.5

EC 2.7.4.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

33708318..33737844

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_680817.9 → XP_685909.5 adenylate kinase 9 isoform X1

UniProtKB/TrEMBL

A0A2R9YJL3, A0A8N7T768

Related

ENSDARP00000118427.2, ENSDART00000135845.4

Conserved Domains (7) summary

COG0563
Location:1258 → 1445

Adk; Adenylate kinase or related kinase [Nucleotide transport and metabolism]

cd01428
Location:33 → 276

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

TIGR01351
Location:33 → 280

adk; adenylate kinase

pfam12018
Location:717 → 804

DUF3508; Domain of unknown function (DUF3508)

pfam13207
Location:394 → 504

AAA_17; AAA domain

cl00909
Location:775 → 808

Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...

cl17190
Location:816 → 983

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_068215655.1 → XP_068071756.1 adenylate kinase 9 isoform X2