U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ppp3cca protein phosphatase 3, catalytic subunit, gamma isozyme, a [ Danio rerio (zebrafish) ]

Gene ID: 557926, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
ppp3ccaprovided by ZNC
Official Full Name
protein phosphatase 3, catalytic subunit, gamma isozyme, aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030829-36
See related
Ensembl:ENSDARG00000014962 AllianceGenome:ZFIN:ZDB-GENE-030829-36
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ppp3cc; sb:cb767; si:dkey-21k4.5
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-mediated signaling. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including hatching gland; musculature system; nervous system; polster; and trigeminal placode. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ppp3cca in Genome Data Viewer
Location:
chromosome: 5
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (27924330..27994672, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (27323003..27394550, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene transcriptional and immune response regulator a Neighboring gene ADAM metallopeptidase domain 28 Neighboring gene VPS37B subunit of ESCRT-I a Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A radiation hybrid map of the zebrafish genome. Geisler R, et al. Nat Genet, 1999 Sep. PMID 10471505
  2. Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Sojan JM, et al. Front Nutr, 2022. PMID 35571926, Free PMC Article
  3. Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. Cao S, et al. Zebrafish, 2023 Feb. PMID 36795618, Free PMC Article
  4. Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Lu Y, et al. Front Mol Neurosci, 2022. PMID 35600071, Free PMC Article
  5. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcineurin-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein phosphatase 3, catalytic subunit, gamma isozyme, a
NP_001160100.1
XP_005171933.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166628.1 → NP_001160100.1  protein phosphatase 3, catalytic subunit, gamma isozyme, a

    Status: VALIDATED

    Source sequence(s)
    AL929297, BX666060, CN326680, EH436386, EH461939, EH548361
    UniProtKB/TrEMBL
    A0A8M1NSY8, A3KGZ6
    Related
    ENSDARP00000121481.1, ENSDART00000132740.3
    Conserved Domains (2) summary
    smart00156
    Location:59 → 327
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:39 → 343
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    27924330..27994672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171876.5 → XP_005171933.1  protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1

    UniProtKB/TrEMBL
    A0A286YA34, A0A8M2BJ63
    Related
    ENSDARP00000144033.2, ENSDART00000175819.2
    Conserved Domains (2) summary
    smart00156
    Location:59 → 327
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:39 → 343
    MPP_PP2B; PP2B, metallophosphatase domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394577.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    392857..413381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395236.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    162198..234198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.