fscn1a fascin actin-bundling protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fscn1aprovided by ZNC
Official Full Name: fascin actin-bundling protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031009-1
See related: Ensembl:ENSDARG00000059680 AllianceGenome:ZFIN:ZDB-GENE-031009-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fscn1; sb:cb589; zgc:153632
Summary: Enables actin filament binding activity; protein-macromolecule adaptor activity; and signaling receptor binding activity. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; neural crest cell migration involved in sympathetic nervous system development; and regulation of nodal signaling pathway. Predicted to be located in cytoskeleton. Predicted to be active in several cellular components, including lamellipodium; microvillus; and ruffle. Is expressed in several structures, including head; mesoderm; nervous system; neural crest; and neural plate. Orthologous to human FSCN1 (fascin actin-bundling protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (40576428..40588858)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (40434570..40447000)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FSCN1 as a new druggable target in adrenocortical carcinoma.
Title: FSCN1 as a new druggable target in adrenocortical carcinoma.
Fscn1 acts as a molecular linker between TGF-beta family type I receptors and the actin filaments to promote the trafficking of internalized receptors from clathrin-coated vesicles to early endosomes during zebrafish endoderm formation.
Title: Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation.
These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation
Title: Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables actin filament binding	ISO Inferred from Sequence Orthology more info	PubMed
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables signaling receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of digestive tract development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of endocrine pancreas development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epiboly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of liver development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration involved in sympathetic nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural crest cell migration involved in sympathetic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of pharyngeal system development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor internalization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within receptor internalization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within regulation of nodal signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in growth cone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fascin actin-bundling protein 1a

Names: fascin homolog 1, actin-bundling protein a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076560.1 → NP_001070028.1 fascin actin-bundling protein 1a

See identical proteins and their annotated locations for NP_001070028.1

Status: PROVISIONAL

Source sequence(s)

BC124405

UniProtKB/TrEMBL

Q08C47

Related

ENSDARP00000077647.4, ENSDART00000083212.5

Conserved Domains (2) summary

cd00257
Location:380 → 491

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...

pfam06268
Location:266 → 375

Fascin; Fascin domain