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ttll4 tubulin tyrosine ligase-like family, member 4 [ Danio rerio (zebrafish) ]

Gene ID: 558702, updated on 18-Sep-2024

Summary

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Official Symbol
ttll4provided by ZNC
Official Full Name
tubulin tyrosine ligase-like family, member 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-313
See related
Ensembl:ENSDARG00000078935 AllianceGenome:ZFIN:ZDB-GENE-070912-313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-67e16.9
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within cellular protein modification process. Predicted to be active in cilium. Is expressed in alar plate midbrain region; immature eye; lens; optic tectum; and optic vesicle. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ttll4 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (14112475..14143371, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (14141281..14176825, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene fer-1 like family member 6 Neighboring gene protein kinase, AMP-activated, gamma 3b non-catalytic subunit Neighboring gene si:ch211-67e16.11 Neighboring gene ATP binding cassette subfamily B member 6 (LAN blood group) b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility. Pathak N, et al. J Biol Chem, 2011 Apr 1. PMID 21262966, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein modification process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tubulin monoglutamylase TTLL4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104938.2 → NP_001098408.2  tubulin monoglutamylase TTLL4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL929266, BC151972
    UniProtKB/TrEMBL
    A0A8M2BFJ4
    Related
    ENSDARP00000098039.1, ENSDART00000114529.3
    Conserved Domains (1) summary
    pfam03133
    Location:102 → 382
    TTL; Tubulin-tyrosine ligase family

  2. NM_001430833.1 → NP_001417762.1  tubulin monoglutamylase TTLL4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL929266
    UniProtKB/TrEMBL
    A0A8M1RM67, F1Q6C4
    Related
    ENSDARP00000103885.2, ENSDART00000108950.4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    14112475..14143371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478862.2 → XP_021334537.1  tubulin monoglutamylase TTLL4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PSM2
    Conserved Domains (1) summary
    pfam03133
    Location:138 → 418
    TTL; Tubulin-tyrosine ligase family
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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