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galnt11 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) [ Danio rerio (zebrafish) ]

Gene ID: 558716, updated on 2-Nov-2024

Summary

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Official Symbol
galnt11provided by ZNC
Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)provided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-998
See related
Ensembl:ENSDARG00000063636 AllianceGenome:ZFIN:ZDB-GENE-060929-998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb921; wu:fc01a10; zgc:153274
Summary
Predicted to enable Notch binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within determination of left/right symmetry. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in otic vesicle; pronephric duct; and solid lens vesicle. Orthologous to several human genes including GALNT11 (polypeptide N-acetylgalactosaminyltransferase 11). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See galnt11 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (7558161..7587395, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (7528842..7558076, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific methyltransferase 2Ca Neighboring gene putative mediator of RNA polymerase II transcription subunit 26 Neighboring gene ATPase H+ transporting V0 subunit a1b Neighboring gene caveolae associated protein 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. Liu S, et al. PLoS Genet, 2022 Dec. PMID 36459505, Free PMC Article
  2. Rare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects. Liu C, et al. Genome Med, 2018 May 30. PMID 29843777, Free PMC Article
  3. Genome-wide association study of kidney function decline in individuals of European descent. Gorski M, et al. Kidney Int, 2015 May. PMID 25493955, Free PMC Article
  4. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. Sun XJ, et al. PLoS One, 2008 Jan 30. PMID 18231586, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC153274

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 11
NP_001070030.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076562.2 → NP_001070030.2  polypeptide N-acetylgalactosaminyltransferase 11

    Status: VALIDATED

    Source sequence(s)
    AW077234, BC124297, EB933090, EB961633, EH485353
    UniProtKB/TrEMBL
    A0A0R4IWF4, A0A8M1NAZ9, F1R7M5, Q08CC3
    Related
    ENSDARP00000087595.4, ENSDART00000093163.6
    Conserved Domains (4) summary
    cd02510
    Location:140 → 435
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG1216
    Location:135 → 468
    GT2; Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism]
    cd00161
    Location:465 → 586
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:465 → 586
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    7558161..7587395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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