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hmgcra 3-hydroxy-3-methylglutaryl-CoA reductase a [ Danio rerio (zebrafish) ]

Gene ID: 559054, updated on 2-Nov-2024

Summary

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Official Symbol
hmgcraprovided by ZNC
Official Full Name
3-hydroxy-3-methylglutaryl-CoA reductase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040401-2
See related
Ensembl:ENSDARG00000052734 AllianceGenome:ZFIN:ZDB-GENE-040401-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hmgcr1; hmgcr1a; zgc:136576; si:ch211-129a6.5
Summary
Predicted to enable hydroxymethylglutaryl-CoA reductase (NADPH) activity. Acts upstream of or within skeletal muscle tissue development. Predicted to be located in endoplasmic reticulum; membrane; and peroxisome. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in brain; gut; inner ear; intestine; and liver. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See hmgcra in Genome Data Viewer
Location:
chromosome: 5
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (50972746..50992744, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (50326153..50346153, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene arylsulfatase family, member K Neighboring gene ceramide transporter 1a Neighboring gene uncharacterized LOC137495632 Neighboring gene ankyrin repeat domain 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Long-term hyperphagia and caloric restriction caused by low- or high-density husbandry have differential effects on zebrafish postembryonic development, somatic growth, fat accumulation and reproduction. Leibold S, et al. PLoS One, 2015. PMID 25799180, Free PMC Article
  2. Coffee polyphenols exert hypocholesterolemic effects in zebrafish fed a high-cholesterol diet. Meguro S, et al. Nutr Metab (Lond), 2013 Oct 3. PMID 24220226, Free PMC Article
  3. Effects of Phenanthrene Exposure on Cholesterol Homeostasis and Cardiotoxicity in Zebrafish Embryos. McGruer V, et al. Environ Toxicol Chem, 2021 Jun. PMID 33523501
  4. Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. Thorpe JL, et al. Dev Cell, 2004 Feb. PMID 14960282
  5. Partial cloning, tissue distribution and effects of epigallocatechin gallate on hepatic 3-hydroxy-3-methylglutaryl-CoA reductase mRNA transcripts in goldfish (Carassius auratus). Cocci P, et al. Gene, 2014 Jul 25. PMID 24835314

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-hydroxy-3-methylglutaryl-CoA reductase a
Names
3-hydroxy-3-methylglutaryl-Coenzyme A reductase 1a
3-hydroxy-3-methylglutaryl-Coenzyme A reductase a
hmgra
NP_001073446.2
XP_005165572.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079977.2 → NP_001073446.2  3-hydroxy-3-methylglutaryl-CoA reductase a

    See identical proteins and their annotated locations for NP_001073446.2

    Status: VALIDATED

    Source sequence(s)
    BX000437
    UniProtKB/TrEMBL
    A0A8M1NCE4, A9JSZ0
    Related
    ENSDARP00000088231.3, ENSDART00000097460.5
    Conserved Domains (3) summary
    cd00643
    Location:461 → 867
    HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
    TIGR00920
    Location:1 → 884
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    cl21543
    Location:88 → 218
    MMPL; MMPL family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    50972746..50992744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165515.5 → XP_005165572.1  3-hydroxy-3-methylglutaryl-CoA reductase a isoform X1

    See identical proteins and their annotated locations for XP_005165572.1

    UniProtKB/TrEMBL
    A0A8M1NCE4, A9JSZ0
    Related
    ENSDARP00000124862.1, ENSDART00000149553.2
    Conserved Domains (3) summary
    cd00643
    Location:461 → 867
    HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
    TIGR00920
    Location:1 → 884
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    cl21543
    Location:88 → 218
    MMPL; MMPL family

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394610.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    102394..124470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001126459.1: Suppressed sequence

    Description
    NM_001126459.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

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