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zbtb12.2 zinc finger and BTB domain containing 12, tandem duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 559081, updated on 28-Oct-2024

Summary

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Official Symbol
zbtb12.2provided by ZNC
Official Full Name
zinc finger and BTB domain containing 12, tandem duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-27
See related
Ensembl:ENSDARG00000070658 AllianceGenome:ZFIN:ZDB-GENE-060503-27
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-222e23.7
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZBTB12 (zinc finger and BTB domain containing 12). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See zbtb12.2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (26956736..26964342, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (27370960..27380144, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene negative elongation factor complex member E Neighboring gene zinc finger and BTB domain containing 12, tandem duplicate 1 Neighboring gene SAC1 like phosphatidylinositide phosphatase a Neighboring gene tumor necrosis factor a (TNF superfamily, member 2)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044884.1 → NP_001038349.1  zinc finger and BTB domain-containing protein 12.2

    See identical proteins and their annotated locations for NP_001038349.1

    Status: PROVISIONAL

    Source sequence(s)
    BX537337
    UniProtKB/TrEMBL
    B7ZVC6, F6P148, Q1LWQ5
    Related
    ENSDARP00000094731.3, ENSDART00000103955.5
    Conserved Domains (5) summary
    smart00225
    Location:32 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:422 → 525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:437 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:435 → 457
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:21 → 123
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    26956736..26964342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170045.4 → XP_005170102.1  zinc finger and BTB domain-containing protein 12.2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHD2
    Conserved Domains (5) summary
    smart00225
    Location:32 → 125
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:421 → 524
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436 → 456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434 → 456
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:21 → 122
    BTB; BTB/POZ domain
Nucleotide Protein
Heading Accession and Version

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