gba2 glucosidase, beta (bile acid) 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gba2provided by ZNC
Official Full Name: glucosidase, beta (bile acid) 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-070522-3
See related: Ensembl:ENSDARG00000061472 AllianceGenome:ZFIN:ZDB-GENE-070522-3
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables beta-glucosidase activity. Acts upstream of or within axonogenesis; central nervous system development; and glucosylceramide metabolic process. Located in plasma membrane. Is expressed in fertilized egg and oocyte. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (24645108..24673134)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (24373947..24402103)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables beta-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucosylceramidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucosylceramide catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucosylceramide metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucosylceramide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

XP_005172389.1

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The following sections contain reference sequences that belong to a specific genome build. Explain