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gcfc2 GC-rich sequence DNA-binding factor 2 [ Danio rerio (zebrafish) ]

Gene ID: 559280, updated on 14-Nov-2024

Summary

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Official Symbol
gcfc2provided by ZNC
Official Full Name
GC-rich sequence DNA-binding factor 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-080204-19
See related
Ensembl:ENSDARG00000079020 AllianceGenome:ZFIN:ZDB-GENE-080204-19
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:171819
Summary
Predicted to enable DNA binding activity. Predicted to act upstream of or within mRNA splicing, via spliceosome. Predicted to be active in nucleus. Orthologous to human GCFC2 (GC-rich sequence DNA-binding factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gcfc2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (32531928..32551259)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (32579405..32599142)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488118 Neighboring gene grainyhead-like transcription factor 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b Neighboring gene uncharacterized LOC108179784 Neighboring gene eva-1 homolog A (C. elegans)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Srag Regulates Autophagy via Integrating into a Preexisting Autophagy Pathway in Testis. Cheng Y, et al. Mol Biol Evol, 2021 Jan 4. PMID 32722765, Free PMC Article
  2. Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal mRNA clearance in zebrafish. Mishima Y, et al. Genes Cells, 2017 Jul. PMID 28557307
  3. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC171819

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
intron Large complex component GCFC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110107.2 → NP_001103577.2  intron Large complex component GCFC2

    Status: VALIDATED

    Source sequence(s)
    CR352331
    UniProtKB/TrEMBL
    A0A8M1NF35
    Related
    ENSDARP00000110163.1, ENSDART00000123399.4
    Conserved Domains (1) summary
    pfam07842
    Location:489 → 685
    GCFC; GC-rich sequence DNA-binding factor-like protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    32531928..32551259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158731.5 → XP_005158788.1  intron Large complex component GCFC2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B5P2
    Conserved Domains (1) summary
    pfam07842
    Location:499 → 695
    GCFC; GC-rich sequence DNA-binding factor-like protein

  2. XM_005158732.5 → XP_005158789.1  intron Large complex component GCFC2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B5M0
    Conserved Domains (1) summary
    pfam07842
    Location:488 → 684
    GCFC; GC-rich sequence DNA-binding factor-like protein
Nucleotide Protein Strain
Heading Accession and Version

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