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syne2b spectrin repeat containing, nuclear envelope 2b [ Danio rerio (zebrafish) ]

Gene ID: 559348, updated on 2-Nov-2024

Summary

Official Symbol
syne2bprovided by ZNC
Official Full Name
spectrin repeat containing, nuclear envelope 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-071218-5
See related
AllianceGenome:ZFIN:ZDB-GENE-071218-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
id:ibd5137; wu:fc12c11; wu:fc31e06; wu:fc62a06; si:dkey-249p9.3; si:dkeyp-77c8.1; si:dkeyp-77c8.2; si:dkeyp-77c8.3; si:dkeyp-77c8.4; si:dkeyp-77c8.5
Summary
Predicted to enable actin binding activity. Acts upstream of or within actin filament organization and epiboly. Predicted to be located in cytoplasm; cytoskeleton; and nuclear outer membrane. Is expressed in several structures, including axis; neural keel; primary neurons; shield; and tail bud. Human ortholog(s) of this gene implicated in autosomal dominant Emery-Dreifuss muscular dystrophy 5. Orthologous to human SYNE2 (spectrin repeat containing nuclear envelope protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See syne2b in Genome Data Viewer
Location:
chromosome: 13
Exon count:
130
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (37075317..37270241, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (36949427..37134867, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487339 Neighboring gene FERM domain containing 6 Neighboring gene estrogen receptor 2b Neighboring gene glycoprotein hormone subunit beta 5 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 5b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epiboly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nesprin-2; spectrin repeat containing, nuclear envelope 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    37075317..37270241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213093.1XP_068069194.1  nesprin-2 isoform X9

  2. XM_068213088.1XP_068069189.1  nesprin-2 isoform X4

  3. XM_068213092.1XP_068069193.1  nesprin-2 isoform X8

  4. XM_068213091.1XP_068069192.1  nesprin-2 isoform X7

  5. XM_068213094.1XP_068069195.1  nesprin-2 isoform X10

  6. XM_068213090.1XP_068069191.1  nesprin-2 isoform X6

  7. XM_068213089.1XP_068069190.1  nesprin-2 isoform X5

  8. XM_068213087.1XP_068069188.1  nesprin-2 isoform X3

  9. XM_068213086.1XP_068069187.1  nesprin-2 isoform X2

  10. XM_068213085.1XP_068069186.1  nesprin-2 isoform X1