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tpd52 tumor protein D52 [ Danio rerio (zebrafish) ]

Gene ID: 559992, updated on 18-Sep-2024

Summary

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Official Symbol
tpd52provided by ZNC
Official Full Name
tumor protein D52provided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-680
See related
Ensembl:ENSDARG00000061713 AllianceGenome:ZFIN:ZDB-GENE-060503-680
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-203l9.2; si:ch211-203l9.3
Summary
Predicted to be involved in B cell differentiation. Predicted to be active in cytoplasm. Orthologous to human TPD52 (tumor protein D52). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See tpd52 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (31904912..31941615)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (32317594..32351836)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909257 Neighboring gene zinc finger and BTB domain containing 10 Neighboring gene zinc finger protein 704 Neighboring gene phosphoprotein membrane anchor with glycosphingolipid microdomains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferation. Kang JW, et al. J Cell Biochem, 2021 Apr. PMID 33166425
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables thymidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tumor protein D52
NP_001038486.1
XP_005159684.1
XP_005159685.1
XP_005159686.1
XP_005159687.1
XP_009292571.1
XP_017207734.1
XP_017207735.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045021.2 → NP_001038486.1  tumor protein D52

    See identical proteins and their annotated locations for NP_001038486.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133913
    UniProtKB/TrEMBL
    A0A8M1N9T8, A3KNM2
    Related
    ENSDARP00000082773.3, ENSDART00000088340.5
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 170
    TPD52; Tumour protein D52 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    31904912..31941615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159630.5 → XP_005159687.1  tumor protein D52 isoform X5

    UniProtKB/TrEMBL
    A0A0R4IDA7, A0A8M2B679
    Related
    ENSDARP00000132427.1, ENSDART00000162297.2
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 193
    TPD52; Tumour protein D52 family

  2. XM_017352246.3 → XP_017207735.1  tumor protein D52 isoform X6

    UniProtKB/TrEMBL
    A0A8M6Z2Z5, I3IT45
    Related
    ENSDARP00000126099.1, ENSDART00000151280.3

  3. XM_009294296.4 → XP_009292571.1  tumor protein D52 isoform X7

    UniProtKB/TrEMBL
    A0A8M3AL07
    Conserved Domains (1) summary
    pfam04201
    Location:48 → 166
    TPD52; Tumour protein D52 family

  4. XM_005159627.5 → XP_005159684.1  tumor protein D52 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B6H9
    Conserved Domains (1) summary
    pfam04201
    Location:48 → 229
    TPD52; Tumour protein D52 family

  5. XM_017352245.3 → XP_017207734.1  tumor protein D52 isoform X3

    UniProtKB/TrEMBL
    A0A8M6YWD3

  6. XM_005159628.5 → XP_005159685.1  tumor protein D52 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B6F1
    Conserved Domains (1) summary
    pfam04201
    Location:48 → 220
    TPD52; Tumour protein D52 family

  7. XM_005159629.5 → XP_005159686.1  tumor protein D52 isoform X4

    UniProtKB/TrEMBL
    A0A8M2B6B7
    Conserved Domains (1) summary
    pfam04201
    Location:48 → 206
    TPD52; Tumour protein D52 family

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395053.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    53832..89453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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