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dvl1b dishevelled segment polarity protein 1b [ Danio rerio (zebrafish) ]

Gene ID: 560032, updated on 2-Nov-2024

Summary

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Official Symbol
dvl1bprovided by ZNC
Official Full Name
dishevelled segment polarity protein 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-071004-1
See related
Ensembl:ENSDARG00000055552 AllianceGenome:ZFIN:ZDB-GENE-071004-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dvl1; dvl2l
Summary
Predicted to enable frizzled binding activity. Predicted to be involved in canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway and intracellular signal transduction. Predicted to be active in cytosol. Is expressed in vertebral column. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to several human genes including DVL1 (dishevelled segment polarity protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See dvl1b in Genome Data Viewer
Location:
chromosome: 11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (24357489..24428510, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (24123040..24191011, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch211-15p9.2 Neighboring gene NFS1 cysteine desulfurase Neighboring gene uncharacterized LOC137496651 Neighboring gene matrix-remodelling associated 8a Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 5a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. Hu T, et al. J Biol Chem, 2010 Apr 30. PMID 20177058, Free PMC Article
  2. The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish. Ségalen M, et al. Dev Cell, 2010 Nov 16. PMID 21074723, Free PMC Article
  3. A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models. Costa R, et al. Hum Mol Genet, 2020 Jan 15. PMID 31816052
  4. pnp4a Is the Causal Gene of the Medaka Iridophore Mutant guanineless. Kimura T, et al. G3 (Bethesda), 2017 Apr 3. PMID 28258112, Free PMC Article
  5. Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity. Mahuzier A, et al. J Cell Biol, 2012 Sep 3. PMID 22927466, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models.
    Title: A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
segment polarity protein dishevelled homolog DVL-1b
Names
dishevelled, dsh homolog 1
dishevelled, dsh homolog 1b
dishevelled, dsh homolog 2, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044917.1 → NP_001038382.1  segment polarity protein dishevelled homolog DVL-1b

    Status: PROVISIONAL

    Source sequence(s)
    BX001056
    UniProtKB/TrEMBL
    A0A2R8QN77, A0A8M1N9G9
    Related
    ENSDARP00000156001.1, ENSDART00000189107.1
    Conserved Domains (5) summary
    smart00021
    Location:1 → 85
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:243 → 330
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:386 → 469
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:90 → 241
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:473 → 697
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    24357489..24428510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169298.5 → XP_005169355.1  segment polarity protein dishevelled homolog DVL-1b isoform X2

    UniProtKB/TrEMBL
    A0A8M2BGJ8, F1QNA4
    Related
    ENSDARP00000094527.4, ENSDART00000103752.5
    Conserved Domains (5) summary
    smart00021
    Location:1 → 85
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:252 → 339
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:395 → 478
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:90 → 250
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:482 → 706
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  2. XM_005169297.5 → XP_005169354.1  segment polarity protein dishevelled homolog DVL-1b isoform X1

    UniProtKB/TrEMBL
    A0A8M2BGK1
    Conserved Domains (5) summary
    smart00021
    Location:1 → 85
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:252 → 339
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:421 → 504
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:90 → 250
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:508 → 732
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  3. XM_005169299.5 → XP_005169356.1  segment polarity protein dishevelled homolog DVL-1b isoform X3

    See identical proteins and their annotated locations for XP_005169356.1

    UniProtKB/TrEMBL
    A0A8M2BGP3
    Conserved Domains (4) summary
    cd00992
    Location:152 → 239
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:321 → 404
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:47 → 150
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:408 → 632
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  4. XM_005169301.5 → XP_005169358.1  segment polarity protein dishevelled homolog DVL-1b isoform X4

    UniProtKB/TrEMBL
    A0A8M2BGL3
    Conserved Domains (4) summary
    smart00021
    Location:1 → 85
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:252 → 339
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:421 → 504
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:90 → 250
    Dishevelled; Dishevelled specific domain
Nucleotide Protein
Heading Accession and Version

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