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myo9b myosin IXb [ Danio rerio (zebrafish) ]

Gene ID: 560956, updated on 12-Sep-2024

Summary

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Official Symbol
myo9bprovided by ZNC
Official Full Name
myosin IXbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-938
See related
Ensembl:ENSDARG00000077410 AllianceGenome:ZFIN:ZDB-GENE-030131-938
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb53f01; wu:fb53f01; wu:fc47c07; si:dkeyp-66d1.8
Summary
Predicted to enable several functions, including ATP binding activity; GTPase activator activity; and actin binding activity. Predicted to act upstream of or within Rho protein signal transduction and actin filament-based movement. Predicted to be part of myosin complex. Human ortholog(s) of this gene implicated in celiac disease. Orthologous to human MYO9B (myosin IXB). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See myo9b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37684922..37744992, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37702465..37762542, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene insulin receptor a Neighboring gene major facilitator superfamily domain containing 14A2 Neighboring gene myeloid associated differentiation marker b Neighboring gene finTRIM family, member 66

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and localization of myosin superfamily members in fish retina and retinal pigmented epithelium. Lin-Jones J, et al. J Comp Neurol, 2009 Mar 10. PMID 19137585, Free PMC Article
  2. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827
  3. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that myo9b is localized in actin-rich ellipsoids of fish cones.
    Title: Identification and localization of myosin superfamily members in fish retina and retinal pigmented epithelium.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin-IXb; unconventional myosin-IXb

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    37684922..37744992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017351952.2 → XP_017207441.1  unconventional myosin-IXb isoform X3

    UniProtKB/TrEMBL
    A0A8M6YVZ6, E9QDU2
    Related
    ENSDARP00000112855.2, ENSDART00000144807.3

  2. XM_005171335.4 → XP_005171392.1  unconventional myosin-IXb isoform X4

    UniProtKB/TrEMBL
    A0A8M2BIN4
    Conserved Domains (5) summary
    smart00242
    Location:147 → 974
    MYSc; Myosin. Large ATPases
    cd00029
    Location:1470 → 1518
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01385
    Location:159 → 965
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:13 → 110
    UBQ; Ubiquitin-like proteins
    cl02570
    Location:1534 → 1719
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  3. XM_009298662.3 → XP_009296937.1  unconventional myosin-IXb isoform X2

    UniProtKB/TrEMBL
    A0A8M3APW7
    Conserved Domains (5) summary
    smart00242
    Location:147 → 974
    MYSc; Myosin. Large ATPases
    cd00029
    Location:1529 → 1577
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01385
    Location:159 → 965
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:13 → 110
    UBQ; Ubiquitin-like proteins
    cl02570
    Location:1593 → 1778
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  4. XM_005171334.5 → XP_005171391.1  unconventional myosin-IXb isoform X1

    UniProtKB/TrEMBL
    A0A8M2BJ44, E7FFP7
    Related
    ENSDARP00000082473.5, ENSDART00000088040.6
    Conserved Domains (5) summary
    smart00242
    Location:147 → 974
    MYSc; Myosin. Large ATPases
    cd00029
    Location:1529 → 1577
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01385
    Location:159 → 965
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:13 → 110
    UBQ; Ubiquitin-like proteins
    cl02570
    Location:1593 → 1778
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  5. XM_009298664.4 → XP_009296939.1  unconventional myosin-IXb isoform X6

    UniProtKB/TrEMBL
    A0A8M3AQC3
    Conserved Domains (5) summary
    smart00242
    Location:147 → 974
    MYSc; Myosin. Large ATPases
    cd00029
    Location:1529 → 1577
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01385
    Location:159 → 965
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:13 → 110
    UBQ; Ubiquitin-like proteins
    cl02570
    Location:1593 → 1778
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  6. XM_009298663.4 → XP_009296938.1  unconventional myosin-IXb isoform X5

    UniProtKB/TrEMBL
    A0A8M3B7U1
    Conserved Domains (5) summary
    smart00242
    Location:147 → 974
    MYSc; Myosin. Large ATPases
    cd00029
    Location:1529 → 1577
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01385
    Location:159 → 965
    MYSc_Myo9; class IX myosin, motor domain
    cl00155
    Location:13 → 110
    UBQ; Ubiquitin-like proteins
    cl02570
    Location:1593 → 1778
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
Nucleotide Protein Strain
Heading Accession and Version

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