U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nlgn4xa neuroligin 4 X-linked a [ Danio rerio (zebrafish) ]

Gene ID: 561122, updated on 19-Jun-2024

Summary

Go to the top of the page Help
Official Symbol
nlgn4xaprovided by ZNC
Official Full Name
neuroligin 4 X-linked aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100309-2
See related
Ensembl:ENSDARG00000079455 AllianceGenome:ZFIN:ZDB-GENE-100309-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
nlgn4a; nlgn4b
Summary
Predicted to enable neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to act upstream of or within cell adhesion. Predicted to be located in cell junction and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface and synapse. Predicted to be integral component of postsynaptic specialization membrane. Is expressed in several structures, including brain; eye; gonad; spinal cord interneuron; and swim bladder. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to several human genes including NLGN4X (neuroligin 4 X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See nlgn4xa in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (32521542..32693355)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (31788979..31959911)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885560 Neighboring gene pseudouridine 5'-phosphatase Neighboring gene uncharacterized LOC562564 Neighboring gene uncharacterized LOC110439944

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential expression of neuroligin genes in the nervous system of zebrafish. Davey C, et al. Dev Dyn, 2010 Feb. PMID 20063411, Free PMC Article
  2. Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Gonçalves C, et al. Genes Brain Behav, 2022 Jun. PMID 35524578, Free PMC Article
  3. Characterization of the neuroligin gene family expression and evolution in zebrafish. Rissone A, et al. Dev Dyn, 2010 Feb. PMID 20034102
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neurexin family protein binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in presynaptic membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
neuroligin 4 X-linked a; neuroligin-4, X-linked
Names
neuroligin 4a
neuroligin 4b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166331.1 → NP_001159803.1  neuroligin 4 X-linked a

    See identical proteins and their annotated locations for NP_001159803.1

    Status: PROVISIONAL

    Source sequence(s)
    GQ892839
    UniProtKB/TrEMBL
    D0EVX4
    Related
    ENSDARP00000110247.1, ENSDART00000128317.3
    Conserved Domains (2) summary
    COG0657
    Location:148 → 263
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:37 → 587
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    32521542..32693355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021475240.1 → XP_021330915.1  neuroligin-4, X-linked isoform X1

    UniProtKB/TrEMBL
    A0A8M9QBU0
    Related
    ENSDARP00000103677.3, ENSDART00000113818.4
    Conserved Domains (1) summary
    pfam00135
    Location:43 → 605
    COesterase; Carboxylesterase family

  2. XM_009292174.3 → XP_009290449.1  neuroligin-4, X-linked isoform X2

    UniProtKB/TrEMBL
    A0A8M3AIZ9, R4GE10
    Related
    ENSDARP00000126721.1, ENSDART00000152580.3
    Conserved Domains (2) summary
    COG0657
    Location:148 → 263
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:39 → 587
    COesterase; Carboxylesterase family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous