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zfp36l1a zinc finger protein 36, C3H type-like 1a [ Danio rerio (zebrafish) ]

Gene ID: 561280, updated on 12-Sep-2024

Summary

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Official Symbol
zfp36l1aprovided by ZNC
Official Full Name
zinc finger protein 36, C3H type-like 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9860
See related
Ensembl:ENSDARG00000016154 AllianceGenome:ZFIN:ZDB-GENE-030131-9860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb198; cb480; fk89d11; zfp36l1; zfp36l2; sb:cb198; sb:cb480; id:ibd1247; wu:fb80h11; wu:fb92f07; wu:fk89d11; zgc:153979
Summary
Predicted to enable metal ion binding activity. Predicted to be located in cytoplasm. Is expressed in several structures, including anterior neural keel; immature eye; nervous system; splanchnocranium; and tail bud. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See zfp36l1a in Genome Data Viewer
Location:
chromosome: 17
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (37790773..37795856, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (37843188..37848271, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 229B Neighboring gene uncharacterized LOC137488131 Neighboring gene uncharacterized LOC103909058 Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zfp36l1b protects angiogenesis through Notch1b/Dll4 and Vegfa regulation in zebrafish. Hu YX, et al. Atherosclerosis, 2020 Sep. PMID 32882641
  2. Efficient disruption of Zebrafish genes using a Gal4-containing gene trap. Balciuniene J, et al. BMC Genomics, 2013 Sep 14. PMID 24034702, Free PMC Article
  3. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
  4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables mRNA 3'-UTR AU-rich region binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mRNA decay activator protein ZFP36L1a
Names
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H type-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077153.2 → NP_001070621.2  mRNA decay activator protein ZFP36L1a

    Status: VALIDATED

    Source sequence(s)
    CR388389
    UniProtKB/TrEMBL
    A0A8M1NB74, F1RCP3
    Related
    ENSDARP00000025205.5, ENSDART00000025853.7
    Conserved Domains (2) summary
    pfam00642
    Location:145 → 170
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam04553
    Location:3 → 127
    Tis11B_N; Tis11B like protein, N terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    37790773..37795856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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