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rabl2 RAB, member of RAS oncogene family-like 2 [ Danio rerio (zebrafish) ]

Gene ID: 561568, updated on 14-Nov-2024

Summary

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Official Symbol
rabl2provided by ZNC
Official Full Name
RAB, member of RAS oncogene family-like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-464
See related
Ensembl:ENSDARG00000063321 AllianceGenome:ZFIN:ZDB-GENE-060503-464
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkeyp-1h4.2
Summary
Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to be active in endomembrane system. Orthologous to human RABL2A (RAB, member of RAS oncogene family like 2A) and RABL2B (RAB, member of RAS oncogene family like 2B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See rabl2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (7639401..7649861)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (7680444..7690926)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 35-30 Neighboring gene ciliary microtubule associated protein 1B Neighboring gene SH3 and multiple ankyrin repeat domains 3a Neighboring gene golgin subfamily A member 6-like protein 22 Neighboring gene arylsulfatase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Isolation, sequence identification and expression profile of three novel genes Rab2A, Rab3A and Rab7A from Black-boned sheep (Ovis aries). He YD, et al. Mol Biol (Mosk), 2010 Jan-Feb. PMID 20198855
  2. Deficiency of the minor spliceosome component U4atac snRNA secondarily results in ciliary defects in human and zebrafish. Khatri D, et al. Proc Natl Acad Sci U S A, 2023 Feb 28. PMID 36802443, Free PMC Article
  3. Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism. James DM, et al. Mol Autism, 2019. PMID 30733854, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RAB, member of RAS oncogene family-like 2
Names
RAB, member of RAS oncogene family-like 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044963.2 → NP_001038428.1  RAB, member of RAS oncogene family-like 2

    See identical proteins and their annotated locations for NP_001038428.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134982
    UniProtKB/TrEMBL
    A0A2R8RZV9, F6NK56, Q1L8G2
    Related
    ENSDARP00000086848.5, ENSDART00000092416.6
    Conserved Domains (2) summary
    cd04124
    Location:20 → 180
    RabL2; Rab GTPase-like family 2 (Rab-like2)
    smart00175
    Location:20 → 169
    RAB; Rab subfamily of small GTPases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    7639401..7649861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293419.4 → XP_009291694.1  RAB, member of RAS oncogene family-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AJE6
    Conserved Domains (2) summary
    smart00175
    Location:20 → 182
    RAB; Rab subfamily of small GTPases
    cl21455
    Location:20 → 193
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395003.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    275282..286309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395333.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    87591..98051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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