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atoh8 atonal bHLH transcription factor 8 [ Danio rerio (zebrafish) ]

Gene ID: 561606, updated on 28-Oct-2024

Summary

Official Symbol
atoh8provided by ZNC
Official Full Name
atonal bHLH transcription factor 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-061215-7
See related
Ensembl:ENSDARG00000037555 AllianceGenome:ZFIN:ZDB-GENE-061215-7
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ath6; zgc:158314
Summary
Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Involved in heart looping and swim bladder formation. Acts upstream of or within heart development; regulation of neural retina development; and regulation of skeletal muscle cell differentiation. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including brain; neural crest cell; optic cup; optic vesicle; and trunk. Orthologous to human ATOH8 (atonal bHLH transcription factor 8). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See atoh8 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (9507329..9522377, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (9201315..9216363, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene RELT like 2 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 5 Neighboring gene uncharacterized LOC100329833 Neighboring gene transmembrane protein 129, E3 ubiquitin protein ligase

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

General gene information

Markers

Clone Names

  • MGC158314

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription factor atoh8
Names
atonal homolog 8
protein atonal homolog 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079991.2NP_001073460.2  transcription factor atoh8

    See identical proteins and their annotated locations for NP_001073460.2

    Status: VALIDATED

    Source sequence(s)
    BX957231
    UniProtKB/Swiss-Prot
    D2CLZ9
    Related
    ENSDARP00000054688.4, ENSDART00000054689.5
    Conserved Domains (1) summary
    pfam00010
    Location:176227
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    9507329..9522377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395311.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    269105..284021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)