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zdhhc4 zinc finger DHHC-type palmitoyltransferase 4 [ Danio rerio (zebrafish) ]

Gene ID: 561817, updated on 18-Sep-2024

Summary

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Official Symbol
zdhhc4provided by ZNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9031
See related
Ensembl:ENSDARG00000045159 AllianceGenome:ZFIN:ZDB-GENE-030131-9031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa97b04; zgc:64155; wu:fa97b04
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC4 (zinc finger DHHC-type palmitoyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See zdhhc4 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (18571461..18577983, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18449587..18456109, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene MTOR associated protein, LST8 homolog (S. cerevisiae) Neighboring gene BRICHOS domain containing 5 Neighboring gene phosphoglycolate phosphatase Neighboring gene glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, b Neighboring gene serine/threonine-protein kinase pim-2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Maddison LA, et al. Mol Genet Genomics, 2009 May. PMID 19221799, Free PMC Article
  2. 2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Wang C, et al. Neurotoxicol Teratol, 2015 Jul-Aug. PMID 26056731
  3. Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Kalén M, et al. Chem Biol, 2009 Apr 24. PMID 19389629, Free PMC Article
  4. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC64155

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC4
Names
probable palmitoyltransferase ZDHHC4
zinc finger DHHC domain-containing protein 4
zinc finger DHHC-type containing 4
zinc finger, DHHC domain containing 4
NP_956343.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200049.2 → NP_956343.2  palmitoyltransferase ZDHHC4

    Status: VALIDATED

    Source sequence(s)
    CT009714
    UniProtKB/Swiss-Prot
    F1QAM1, Q7T323
    Related
    ENSDARP00000150172.1, ENSDART00000193262.1
    Conserved Domains (1) summary
    pfam01529
    Location:152 → 296
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    18571461..18577983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394835.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    537941..544467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1QAM1.1 GenPept UniProtKB/Swiss-Prot:F1QAM1

Gene LinkOut

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