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cep162 centrosomal protein 162 [ Danio rerio (zebrafish) ]

Gene ID: 562035, updated on 2-Nov-2024

Summary

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Official Symbol
cep162provided by ZNC
Official Full Name
centrosomal protein 162provided by ZNC
Primary source
ZFIN:ZDB-GENE-100922-266
See related
Ensembl:ENSDARG00000087369 AllianceGenome:ZFIN:ZDB-GENE-100922-266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-198c19.2
Summary
Involved in cilium assembly. Acts upstream of or within heart looping. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton and nucleoplasm. Is expressed in head. Orthologous to human CEP162 (centrosomal protein 162). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cep162 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (37891782..37944483)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (37941752..37994457)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487948 Neighboring gene si:ch211-198c19.1 Neighboring gene si:ch211-198c19.3 Neighboring gene melanocortin 2 receptor accessory protein 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base. Wang WJ, et al. Nat Cell Biol, 2013 Jun. PMID 23644468, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axonemal microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
centrosomal protein of 162 kDa
Names
protein QN1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353863.1 → NP_001340792.1  centrosomal protein of 162 kDa

    Status: VALIDATED

    Source sequence(s)
    BX088579
    UniProtKB/Swiss-Prot
    E7F5E1
    UniProtKB/TrEMBL
    A0A8M9PDT4
    Related
    ENSDARP00000121710.1, ENSDART00000142104.2
    Conserved Domains (3) summary
    cl25732
    Location:574 → 1332
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:428 → 517
    DUF4045; Domain of unknown function (DUF4045)
    cl28033
    Location:202 → 488
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    37891782..37944483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213979.1 → XP_068070080.1  centrosomal protein of 162 kDa isoform X1

  2. XM_068213980.1 → XP_068070081.1  centrosomal protein of 162 kDa isoform X2

  3. XM_068213981.1 → XP_068070082.1  centrosomal protein of 162 kDa isoform X3

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394968.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    162550..214689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E7F5E1.1 GenPept UniProtKB/Swiss-Prot:E7F5E1

Gene LinkOut

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