U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

arhgef12a Rho guanine nucleotide exchange factor (GEF) 12a [ Danio rerio (zebrafish) ]

Gene ID: 562455, updated on 17-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
arhgef12aprovided by ZNC
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 12aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-121017-3
See related
Ensembl:ENSDARG00000030532 AllianceGenome:ZFIN:ZDB-GENE-121017-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
arhgef12
Summary
Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be located in cytoplasm and membrane. Orthologous to human ARHGEF12 (Rho guanine nucleotide exchange factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See arhgef12a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (22446322..22537374)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (22510386..22601640)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene OAF homolog a (Drosophila) Neighboring gene TLC domain containing 5a Neighboring gene uncharacterized LOC103908836 Neighboring gene glutamate receptor, ionotropic, kainate 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage. Baek S, et al. Dev Cell, 2019 Apr 22. PMID 31014480
  2. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Xie Y, et al. Haematologica, 2020 Apr. PMID 31467124, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within erythrocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rho guanine nucleotide exchange factor 12
Names
Rho guanine nucleotide exchange factor (GEF) 12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    22446322..22537374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291731.4 → XP_009290006.1  rho guanine nucleotide exchange factor 12 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AHH6, E7FDV8
    Related
    ENSDARP00000040541.5, ENSDART00000040542.7
    Conserved Domains (4) summary
    cd00992
    Location:66 → 140
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00621
    Location:743 → 928
    RhoGEF; RhoGEF domain
    cl02565
    Location:308 → 524
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl17171
    Location:947 → 1083
    PH-like; Pleckstrin homology-like domain

  2. XM_009291733.4 → XP_009290008.1  rho guanine nucleotide exchange factor 12 isoform X3

    UniProtKB/TrEMBL
    A0A2R8QD00, A0A8M3AIL3
    Related
    ENSDARP00000149601.1, ENSDART00000190270.1
    Conserved Domains (4) summary
    cd00992
    Location:47 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00621
    Location:724 → 909
    RhoGEF; RhoGEF domain
    cl02565
    Location:289 → 505
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl17171
    Location:928 → 1064
    PH-like; Pleckstrin homology-like domain

  3. XM_068213719.1 → XP_068069820.1  rho guanine nucleotide exchange factor 12 isoform X2

    Related
    ENSDARP00000152634.1, ENSDART00000185897.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.