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depdc5 DEP domain containing 5, GATOR1 subcomplex subunit [ Danio rerio (zebrafish) ]

Gene ID: 562995, updated on 18-Sep-2024

Summary

Official Symbol
depdc5provided by ZNC
Official Full Name
DEP domain containing 5, GATOR1 subcomplex subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-091204-356
See related
Ensembl:ENSDARG00000078105 AllianceGenome:ZFIN:ZDB-GENE-091204-356
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-106l3.5
Summary
Predicted to contribute to GTPase activator activity. Acts upstream of or within regulation of neuronal action potential and swimming behavior. Predicted to be part of GATOR1 complex. Predicted to be active in lysosomal membrane. Is expressed in central nervous system and notochord. Used to study focal epilepsy. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See depdc5 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (17171254..17222162, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (17213290..17264174, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide Neighboring gene uncharacterized LOC110440068 Neighboring gene RAB36, member RAS oncogene family Neighboring gene guanine nucleotide binding protein (G protein), alpha z polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of GATOR1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
DEP domain-containing protein 5; GATOR1 complex protein DEPDC5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    17171254..17222162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_686358.9XP_691450.5  GATOR1 complex protein DEPDC5 isoform X3

    UniProtKB/TrEMBL
    A0A8N7UT47, E7EXM8
    Related
    ENSDARP00000098526.3, ENSDART00000111088.4
    Conserved Domains (2) summary
    cd04449
    Location:11731256
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:111385
    DUF3608; Protein of unknown function (DUF3608)
  2. XM_021479301.2XP_021334976.1  GATOR1 complex protein DEPDC5 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QGW7
    Conserved Domains (2) summary
    cd04449
    Location:11751258
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:111385
    IML1; Vacuolar membrane-associated protein Iml1
  3. XM_021479304.2XP_021334979.1  GATOR1 complex protein DEPDC5 isoform X5

    UniProtKB/TrEMBL
    A0A8M9QCD7
    Related
    ENSDARP00000115238.1, ENSDART00000134059.3
    Conserved Domains (2) summary
    cd04449
    Location:11631246
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:111385
    IML1; Vacuolar membrane-associated protein Iml1
  4. XM_021479302.2XP_021334977.1  GATOR1 complex protein DEPDC5 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PTY0
    Conserved Domains (2) summary
    cd04449
    Location:11841267
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:111385
    IML1; Vacuolar membrane-associated protein Iml1
  5. XM_021479300.2XP_021334975.1  GATOR1 complex protein DEPDC5 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QKY4
    Conserved Domains (2) summary
    cd04449
    Location:11841267
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:111385
    IML1; Vacuolar membrane-associated protein Iml1
  6. XM_068223938.1XP_068080039.1  GATOR1 complex protein DEPDC5 isoform X6