chkb choline kinase beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chkbprovided by ZNC
Official Full Name: choline kinase betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2928
See related: Ensembl:ENSDARG00000063167 AllianceGenome:ZFIN:ZDB-GENE-030131-2928
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc21g05; wu:fc21g05; si:ch211-218c17.2
Summary: Predicted to enable choline kinase activity and ethanolamine kinase activity. Predicted to be involved in CDP-choline pathway and phosphatidylethanolamine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (8320199..8337571)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (8362146..8379552)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables choline kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ethanolamine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ethanolamine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-choline pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: choline/ethanolamine kinase

NP_001093482.1

EC 2.7.1.82

XP_005159071.1

EC 2.7.1.82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100012.2 → NP_001093482.1 choline/ethanolamine kinase

See identical proteins and their annotated locations for NP_001093482.1

Status: PROVISIONAL

Source sequence(s)

BX276107, CR936412

UniProtKB/TrEMBL

B3DJJ3, Q1LXT9

Related

ENSDARP00000086486.5, ENSDART00000092053.6

Conserved Domains (2) summary

PLN02236
Location:118 → 450

PLN02236; choline kinase

cd05156
Location:130 → 448

ChoK_euk; Euykaryotic Choline Kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

8320199..8337571

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159014.4 → XP_005159071.1 choline/ethanolamine kinase isoform X1

UniProtKB/TrEMBL

A0A8M2B5G6

Conserved Domains (1) summary

cd05156
Location:130 → 374

ChoK_euk; Euykaryotic Choline Kinase