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ash1l ash1 (absent, small, or homeotic)-like (Drosophila) [ Danio rerio (zebrafish) ]

Gene ID: 563799, updated on 2-Nov-2024

Summary

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Official Symbol
ash1lprovided by ZNC
Official Full Name
ash1 (absent, small, or homeotic)-like (Drosophila)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6101
See related
Ensembl:ENSDARG00000070981 AllianceGenome:ZFIN:ZDB-GENE-030131-6101
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi34d11; wu:fi34d11; si:ch211-81a5.3
Summary
Predicted to enable histone H3K4 methyltransferase activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 52. Orthologous to human ASH1L (ASH1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See ash1l in Genome Data Viewer
Location:
chromosome: 19
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (9032355..9086941)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (9113411..9168016)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene secretory carrier membrane protein 3 Neighboring gene ring finger protein 115b Neighboring gene leucine rich repeat containing 71 Neighboring gene SET domain bifurcated histone lysine methyltransferase 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. Sun XJ, et al. PLoS One, 2008 Jan 30. PMID 18231586, Free PMC Article
  2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K4 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase ASH1L
NP_001333336.1
XP_005159540.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346407.1 → NP_001333336.1  histone-lysine N-methyltransferase ASH1L

    Status: VALIDATED

    Source sequence(s)
    CR626935
    UniProtKB/TrEMBL
    A0A8M1P9K9, F1QSJ1, F1QY85
    Related
    ENSDARP00000105655.3, ENSDART00000127755.5

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    9032355..9086941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159483.5 → XP_005159540.1  histone-lysine N-methyltransferase ASH1L isoform X1

    See identical proteins and their annotated locations for XP_005159540.1

    UniProtKB/TrEMBL
    A0A0R4J6P5, A0A8M2B6D3
    Related
    ENSDARP00000052914.6, ENSDART00000052915.8
    Conserved Domains (7) summary
    cd05525
    Location:2408 → 2513
    Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...
    smart00570
    Location:2037 → 2088
    AWS; associated with SET domains
    smart00317
    Location:2091 → 2238
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5076
    Location:2281 → 2500
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    cd04717
    Location:2633 → 2772
    BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
    cd15548
    Location:2559 → 2601
    PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
    pfam09786
    Location:529 → 674
    CytochromB561_N; Cytochrome B561, N terminal
Nucleotide Protein Strain
Heading Accession and Version

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