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chac1 ChaC, cation transport regulator homolog 1 (E. coli) [ Danio rerio (zebrafish) ]

Gene ID: 563855, updated on 12-Sep-2024

Summary

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Official Symbol
chac1provided by ZNC
Official Full Name
ChaC, cation transport regulator homolog 1 (E. coli)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1957
See related
Ensembl:ENSDARG00000070426 AllianceGenome:ZFIN:ZDB-GENE-030131-1957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb1014; wu:fb93a10; wu:fp64e03
Summary
Predicted to enable Notch binding activity and gamma-glutamylcyclotransferase activity. Acts upstream of or within with a positive effect on glutathione catabolic process. Predicted to be located in trans-Golgi network. Predicted to be active in cytoplasm. Is expressed in several structures, including alar plate midbrain region; nervous system; optic vesicle; periderm; and solid lens vesicle. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See chac1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (28266935..28269464)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (28367845..28370374)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene synapse differentiation inducing 1-like Neighboring gene delta-like 4 (Drosophila) Neighboring gene INO80 complex ATPase subunit Neighboring gene VPS18 core subunit of CORVET and HOPS complexes

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium. Yadav S, et al. Biochem J, 2019 Jul 2. PMID 31189567
  2. Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood. Hartig EI, et al. BMC Res Notes, 2020 Aug 3. PMID 32746894, Free PMC Article
  3. Expression profiling and comparative genomics identify a conserved regulatory region controlling midline expression in the zebrafish embryo. Dickmeis T, et al. Genome Res, 2004 Feb. PMID 14718378, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study thus identifies Chac1 and the consequent change in intracellular glutathione redox potential as important upstream activators of calcium signaling during development.
    Title: The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC4504, MGC173477, MGC173478

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Notch binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutathione specific gamma-glutamylcyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione specific gamma-glutamylcyclotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within_positive_effect glutathione catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_positive_effect glutathione catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein processing ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutathione-specific gamma-glutamylcyclotransferase 1
Names
ChaC, cation transport regulator-like 1
cation transport regulator-like protein 1
gamma-GCG 1
NP_001103596.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110126.2 → NP_001103596.2  glutathione-specific gamma-glutamylcyclotransferase 1

    See identical proteins and their annotated locations for NP_001103596.2

    Status: VALIDATED

    Source sequence(s)
    BC153392, CK400274
    UniProtKB/Swiss-Prot
    Q5SPB6
    UniProtKB/TrEMBL
    A4QNY6
    Related
    ENSDARP00000094107.4, ENSDART00000103330.5
    Conserved Domains (2) summary
    COG3703
    Location:5 → 190
    ChaC; Cation transport regulator ChaC [Inorganic ion transport and metabolism]
    pfam04752
    Location:13 → 183
    ChaC; ChaC-like protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    28266935..28269464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SPB6.1 GenPept UniProtKB/Swiss-Prot:Q5SPB6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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